176969-34-9Relevant articles and documents
PRODUCING METHOD FOR 3-DIFLUOROMETHYLPYRAZOLE COMPOUND, PRODUCING METHOD FOR 3-DIFLUOROMETHYLPYRAZOLE-4-CARBOXYLIC ACID COMPOUND, AND PYRAZOLIDINE COMPOUND
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Paragraph 0185-0189, (2021/03/05)
Provided are producing methods for a 3-difluoromethylpyrazole compound and a 3-difluoromethylpyrazole-4-carboxylic acid compound, which include, in a reaction solvent containing a specific solvent, subjecting a difluoroacetyl group-containing compound, a hydrazine compound, and formaldehyde to a cyclocondensation reaction, and subsequently oxidizing the obtained pyrazole compound precursor, and a pyrazolidine compound represented by a specific formula in these producing methods.
PRODUCTION METHOD FOR HALOGENATED PYRAZOLECARBOXYLIC ACID
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Page/Page column 0081-0095, (2020/01/24)
The invention provides a method capable of more simply and efficiently producing halogen-containing pyrazolecarboxylic acids useful as pharmaceutical or agrochemical intermediates, in a manner suitable for industrial production. In particular, the invention provides a method of producing a compound represented by the formula (b), which comprises reacting a compound represented by the formula (a) with oxygen in the presence of a compound containing a transition metal atom to obtain the compound represented by the formula (b): wherein each symbol is as described in the description.
Synthesis and biological activity of acyl thiourea containing difluoromethyl pyrazole motif
Min, Li-Jing,Zhai, Zhi-Wen,Shi, Yan-Xia,Han, Liang,Tan, Cheng-Xia,Weng, Jian-Quan,Li, Bao-Ju,Zhang, Yong-Gang,Liu, Xing-Hai
, p. 22 - 28 (2019/07/12)
A series of new acyl thiourea derivatives containing difluoromethyl pyrazole moiety were designed and synthesized. Their structures were confirmed by 1H NMR, 31C NMR, MS and HRMS. The bioassay results showed that some of title compounds exhibited good in vivo fungicidal activity against Botrytis cinerea and Fusarium oxysporum and good antibacterial activity against Pseudomonas syringae pv. Lachrymans at 50 mg/L respectively.