148546-99-0

Basic information

• Product Name: 3-(4-Methylpiperazin-1-yl)aniline
• Synonyms: 3-(4-Methylpiperazin-1-yl)aniline ,97%;3-(4-methylpiperazin-1-yl)benzenamine;Benzenamine, 3-(4-methyl-1-piperazinyl)-;3-(4-Methypiperazin-1-yl)anilin;1-(3-Aminophenyl)-4-methylpiperazine;3-(4-Methyl-1-piperazinyl)aniline;3-(4-METHYLPIPERAZIN-1-YL)ANILINE;AKOS BB-8951
• CAS NO: 148546-99-0
• Molecular Formula: C₁₁H₁₇N₃
• Molecular Weight: 191.27
• Product Categories: Amines and Anilines;PIPERIDINE
• Mol File: 148546-99-0.mol
• Article Data: 33

Chemical Properties

• Melting Point: 98-99
• Boiling Point: 353.082 °C at 760 mmHg
• Flash Point: 164.907 °C
• Appearance: /
• Density: 1.093 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 7.88±0.42(Predicted)
• CAS DataBase Reference: 3-(4-Methylpiperazin-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methylpiperazin-1-yl)aniline(148546-99-0)
• EPA Substance Registry System: 3-(4-Methylpiperazin-1-yl)aniline(148546-99-0)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-34
• Safety Statements: 22-26-36/37/39-45
• RIDADR: 2923
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 148546-99-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

Upstream product

• 148546-97-8 1‐methyl‐4‐(3‐nitrophenyl)piperazine 
• 109-01-3 1-methyl-piperazine 
• 108-37-2 1-bromo-3-chlorobenzene 
• 645-00-1 m-iodonitrobenzene 
• 585-79-5 m-nitrobromobenzene 
• 54054-85-2 1-(3-nitrophenyl)piperazine 
• 402-67-5 3-fluoro-1-nitrobenzene 

Downstream Products

• 378759-37-6 1-(3'-benzyloxycarbonylaminophenyl)-4-methylpiperazine 
• 209481-70-9 naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]amide 
• 182618-68-4 (+)-N-[5-Cycloheptyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'-[3-(N-methyl-N'-piperazinyl)phenyl]urea 
• 1042435-00-6 ethyl 2-[(5-chloro-2-{[3-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]benzoate 
• 1042435-03-9 Ethyl 2-[(5-fluoro-2-{[3-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]benzoate 
• 1042435-05-1 Ethyl 2-[(5-methyl-2-{[3-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]benzoate 
• 927653-64-3 4-[1-methyl-3-(4-nitro-phenyl)-1H-pyrazol-4-yl]-N-[3-(4-methyl-piperazin-1-yl)phenyl]-pyrimidin-2-amine 
• 1232398-47-8 [7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine 

Relevant articles and documents

PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF

The present invention discloses a pyrimidine compound, a preparation method thereof and a medical use thereof. Specifically, the present invention discloses a pyrimidine compound represented by formula (I), pharmaceutically acceptable salts thereof, a preparation method thereof, and a use thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor, particularly for the treatment of cancer. The definition of each group in formula (I) is the same as that in the specification.

Discovery of novel 4-azaaryl-N-phenylpyrimidin-2-amine derivatives as potent and selective FLT3 inhibitors for acute myeloid leukaemia with FLT3 mutations

Feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3) is one of the most pursued targets in the treatment of acute myeloid leukaemia (AML) as its gene amplification and mutations, particularly internal tandem duplication (ITD), contribute to the pa

Catalyst-Directed Chemoselective Double Amination of Bromo-chloro(hetero)arenes: A Synthetic Route toward Advanced Amino-aniline Intermediates

A chemoselective sequential one-pot coupling protocol was developed for preparing several amino-anilines in high yield as building blocks for active pharmaceutical ingredients (APIs). Site (Cl vs Br on electrophile) and nucleophile (amine vs imine) selectivity is dictated by the catalyst employed. A Pd-crotyl(t-BuXPhos) precatalyst selectively coupled the Ar-Br of the polyhaloarene with benzophenone imine, even in the presence of a secondary amine, while Pd-based RuPhos or (BINAP)Pd(allyl)Cl coupled the Ar-Cl site with secondary amines.