133628-28-1

Basic information

• Product Name: BOC-LYS(FMOC)-OME
• Synonyms: BOC-LYSINE(FMOC)-OME;BOC-LYS(FMOC)-OME;BOC-N-EPSILON-FMOC-L-LYSINE METHYL ESTER;N-T-BUTOXYCARBONYL-N-9-FLUORENYLMETHOXYCARBONYL-L-LYSINE METHYL ESTER;N2-[(1,1-Dimethylethoxy)Carbonyl]-N6-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Lysine Methyl Ester;Boc-L-Lys(Fmoc)-OMe;Nα-Boc-Nε-Fmoc-L-lysine methyl ester≥ 98% (HPLC);Nalpha-Boc-Nepsilon-Fmoc-L-lysine methyl ester
• CAS NO: 133628-28-1
• Molecular Formula: C27H34N2O6
• Molecular Weight: 482.57
• Mol File: 133628-28-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 653.7±55.0 °C(Predicted)
• Appearance: White to off-white/Powder
• Density: 1.169±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.16±0.46(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: BOC-LYS(FMOC)-OME(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-LYS(FMOC)-OME(133628-28-1)
• EPA Substance Registry System: BOC-LYS(FMOC)-OME(133628-28-1)

Safety Data

• Hazardous Substances Data: 133628-28-1(Hazardous Substances Data)

Usage

Uses

It is employed as a intermediate for pharmaceutical.

Upstream product

• 84624-27-1 Boc-Lys(Fmoc)-OH 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 

Downstream Products

• 84624-27-1 Boc-Lys(Fmoc)-OH 

Relevant articles and documents

Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins

A series of 2- and 3-nitrothiophene-5-carboxamides bearing N-(ω-aminoalkyl) side chains has been prepared by treatment of the thiophenecarbonyl chloride with the appropriate (protected) ω-aminoalkylamine. Analogous N-(oxiranylmethyl)nitrothiophene-5-carboxamides have been synthesized by epoxidation of the corresponding N-allylamide. Compounds in both classes were evaluated in vitro both as radiosensitizers of hypoxic mammalian cells and as selective bioreductively activated cytotoxins. The most potent radiosensitizers were those agents with strong tertiary amine bases or oxiranes in the side chain. Studies in vivo showed that 2-methyl-N-[2-(dimethylamino)ethyl]-3-nitrothiophene-5-carboxamide caused slight radiosensitization of the KHT sarcoma in mice given 0.34 mmol kg-1. However, administration of this and related tertiary amines at higher doses was precluded by systemic toxicity.