13139-28-1

Basic information

• Product Name: Z-VAL-NH2
• Synonyms: N-ALPHA-CARBOBENZOXY-L-VALINE AMIDE;Z-L-VALINE AMIDE;Z-VAL-NH2;CBZ-L-VALINE AMIDE;(S)-benzyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate;CBZ-Val-NH2;N-Benzyloxycarbonyl-L-valinamide;(S)-N-(Benzyloxycarbonyl)valinamide
• CAS NO: 13139-28-1
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.29
• Mol File: 13139-28-1.mol
• Article Data: 24

Chemical Properties

• Appearance: /Solid
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: Z-VAL-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-VAL-NH2(13139-28-1)
• EPA Substance Registry System: Z-VAL-NH2(13139-28-1)

Safety Data

• Hazardous Substances Data: 13139-28-1(Hazardous Substances Data)

Usage

General Description

Z-VAL-NH2, also known as Z-Valine amide, is a compound consisting of a peptide chain with the amino acid valine at its core. This chemical is commonly used in peptide synthesis and research as a building block for creating larger peptide molecules. Valine is one of the essential amino acids that the body needs for protein synthesis and is involved in various metabolic processes. Z-VAL-NH2 can be utilized as a precursor for the creation of specific peptides with biological functions, and its properties make it a valuable tool in the field of biochemistry and pharmaceutical research.

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 501-53-1 benzyl chloroformate 
• 2018-66-8 Z-Leu-OH 
• 17498-50-9 L-valine hydrochloride 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 72-18-4 L-valine 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 119153-86-5 C₁₆H₂₁NO₆ 
• 79479-05-3 Z-Val-pGlu-NH₂ 
• 24210-19-3 methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate 

Downstream Products

• 4540-60-7 L-valinamide 
• 125453-20-5 [1-(1-Benzotriazol-1-yl-3-methyl-butylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 184034-17-1 Cbz-Val-(E)-Aba-OH 
• 182866-67-7 2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-3-phenyl-propionic acid ethyl ester 
• 182866-66-6 2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester 
• 203782-30-3 2-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-oxo-butyric acid methyl ester 
• 203782-28-9 [(S)-1-(4-Carbamoyl-5-methyl-oxazol-2-yl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 1263315-48-5 benzyl (2S,3R)-2-isopropyl-5-oxopyrrolidin-3-ylcarbamate 
• 1263315-49-6 (2S,3R)-tert-butyl 3-(benzyloxycarbonylamino)-2-isopropyl-5-oxopyrrolidine-1-carboxylate 
• 1263315-51-0 (3R,4S) 3-(benzyloxycarbonylamino)-4-(tertbutoxycarbonylamino)-5-methylhexanoic acid 
• 1415109-61-3 C₂₆H₄₁N₃O₇ 
• 1415109-63-5 C₂₁H₃₃N₃O₅ 
• 1415109-66-8 C₂₉H₄₆N₄O₈ 
• 1415109-69-1 C₃₂H₅₂N₄O₈ 

Relevant articles and documents

Nomega-linked arginine peptides.

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Evaluation of Amino Nitriles and an Amino Imidate as Organo?-catalysts in Aldol Reactions

The efficiency of l -valine and l -proline nitriles and a tert -butyl?- l -proline imidate as organocatalysts for the aldol reaction have been evaluated. l -Valine nitrile was found to be a syn -selective catalyst, while l -proline nitrile was found to be anti -selective, and gave products in modest to good enantioselectivities. tert -Butyl l -proline imidate was found to be a very efficient catalyst in terms of conversion of starting reagents to products, and gave good anti -selectivity. The enantioselectivity of the tert -butyl l -proline imidate was found to be good to excellent, with products being formed in up to 94percent enantiomeric excess.

Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine

Primary amidations of carboxylic acids 1 or 3 with NH4Cl in the presence of ClCO2Et and Et3N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of various amides containing hydroxamic acids and achieved the synthesis of (1S,2R)-tranylcypromine as an antidepressant medicine via Lossen rearrangement.