104-04-1Relevant articles and documents
Acidified, wet, silica-supported tetrabutylammonium periodate: A convenient and mild reagent for conversion of thioamides to their corresponding amides under solvent-free conditions
Nasr-Esfahani, Masoud,Moghadam, Majid,Mohammadpoor-Baltork, Iraj,Boostanifar, Mohammad Hasan
, p. 2004 - 2009 (2009)
A series of thioamides are transformed to their corresponding oxo analogues in good to excellent yields with acidified, wet, silica-supported tetrabutylammonium periodate under solvent-free conditions.
On the mechanism for the photooxidation of aromatic azides containing a secondary N–H bond: A sequence of intramolecular transformations with the formation of heterocyclic oximes
Chainikova, Ekaterina,Khursan, Sergey,Yusupova, Alfia,Lobov, Alexander,Abdullin, Marat,Safiullin, Rustam
, p. 3267 - 3271 (2018)
During the photooxidation of aromatic azides containing a secondary N–H bond at the para-position, a sequence of intramolecular transformations of nitroso oxides led to the formation of heterocyclic oximes along with the corresponding nitroso and nitro co
NOVEL DESULFURIZATION OF THIOCARBONYL COMPOUNDS INTO THEIR CARBONYL COMPOUNDS WITH TERTIARY BUTYL THIONITRATE
Kim, Jin Hyung,Kim, Yong Hae
, p. 1669 - 1670 (1987)
Various thiocarbonyl compounds such as thioamides, thiocarbamate, thiocarbonate, trithiocarbonate and thioketone were readily reacted with t-butyl thionitrate (t-BuSNO2) to give the corresponding carbonyl compounds in excellent yields under mild conditions.Desulfurization seems to be initiated via the selective nitrosation on the sulfur atom of thiocarbonyl group with t-BuSNO2.
NOVEL DESULFURIZATION OF THIOCARBONYL COMPOUNDS INTO THEIR CORRESPONDING OXO-DERIVATIVES USING A PEROXY-SULFUR INTERMEDIATE GENERATED FROM 2-NITROBENZENESULFONYL CHLORIDE AND SUPEROXIDE ANION.
Kim, Yong Hae,Chung, Bong Chul,Chang, Hae Sung
, p. 1079 - 1082 (1985)
Thiocarbonyl compounds such as substituted-thioureas, -thioamides, and -thiocarbamates were found to react with a peroxysulfur intermediate (3) which is generated by the treatment of 2-nitrobenzenesulfonyl chloride with potassium superoxide to convert into the corresponding carbonyl compounds in quantitative yield at -30 oC in acetonitrile.
Transformation of thioamide compounds to corresponding amides using 12-Tungstosilicic acid
Nasr-Esfahani, Masoud,Montazerozohori, Morteza,Moghadam, Majid,Mohammadpoor-Baltork, Iraj,Moradi, Sareh
, p. 261 - 266 (2010)
12-Tungstosilicic acid (H4SiW12O40) is applied for the conversion of a series of thioamides to their corresponding oxo analogues in excellent yields in acetonitrile. In the case of thioketones, no reaction is observed under these conditions. The reusability of the catalyst also is investigated.
Synthesis of ring-opened derivatives of triazole-containing quinolinones and their antidepressant and anticonvulsant activities
Song, Ming-Xia,Huang, Yu-Shan,Zhou, Qiu-Gui,Deng, Xian-Qing,Yao, Xiao-Dong
, (2021)
Based on the potent antidepressant and anticonvulsant activities of the triazole-containing quinolinones reported in our previous work, a series of ring-opened derivatives of them were designed, synthesized in this work. Their antidepressant and anticonvulsant activities were screened using the forced swimming test (FST) and the maximal electroshock seizure test (MES), respectively. The results showed that compounds 4a, 5a, 6c-6e, 6g-6i, and 7 led to significant reductions in the accumulated immobility time in the FST at a dose of 50 mg/kg. Especially compound 7 exhibited higher levels of efficacy than the reference standard fluoxetine in the FST and the tail suspension test. The results of an open field test excluded the possibility of central nervous stimulation of 7, which further confirmed its antidepressant effect. Meanwhile, compounds 6a-6i and 7 showed different degrees of anticonvulsant activity in mice at the doses range from 300 to 30 mg/kg in the MES. Among them, compounds 6e and 7 displayed the ED50 of 38.5 and 32.7 mg/kg in the MES, and TD50 of 254.6 and 245.5 mg/kg, respectively. No one showed neurotoxicity at the dose of 100 mg/kg. The preliminary investigation forward to their mechanism indicated that regulation of GABAergic system might contribute to their anticonvulsive and anti-depressive action.
A mild and convenient method for conversion of thioamides to their corresponding amides using acidified wet silica-supported permanganate under solvent-free conditions
Nasr-Esfahani, Masoud,Moghadam, Majid,Mohammadpoor-Baltork, Iraj,Boostanifar, Mohammad Hasan
, p. 141 - 146 (2009)
A mild and efficient method for conversion of thioamides to their corresponding amides is reported. A series of thioamides are transformed to their corresponding carbonyl compounds in good to excellent yields by acidified wet silica-supported permanganate under solid phase conditions.
Synthesis and conformational analysis of N-aryl-N-(3-thienyl)acetamides
Ito, Ai,Asami, Yuki,Asato, Marino,Fukuda, Kazuo,Yamasaki, Ryu,Okamoto, Iwao
, p. 2454 - 2458 (2018)
The cis-trans conformational equilibrium of amides is of interest because it can be used to control functional activity. Here, we designed and synthesized a series of N-(3-thienyl)amides in order to study the factors affecting their conformational equilibrium. NMR studies showed that the major conformer of N-methyl-N-(3-thienyl)amide in solution is the E-form (cis form), as is the case for N-methylacetamide. For N-aryl-N-(3-thienyl)amides bearing an N-phenyl moiety, the major conformers differ depending on not only the relative π-electron density of the N-aryl moiety, but also its size. X-ray analysis showed that their solid-state conformational preferences were similar to those in solution.
Ruthenium(III) chloride catalyzed acylation of alcohols, phenols, thiols, and amines
Kanta De, Surya
, p. 2919 - 2922 (2004)
Ruthenium(III) chloride catalyzes the acylation of a variety of phenols, alcohols, thiols, and amines under mild conditions. Some of the major advantages of this method are high yields, short reaction times, ease of operation, and compatibility with other protecting groups.
Ortho-Selective Nitration of Acetanilides with Nitrogen Dioxide in the Presence of Ozone
Suzuki, Hitomi,Ishibashi, Taro,Murashima, Takashi,Tsukamoto, Kenkichi
, p. 6591 - 6594 (1991)
In the presence of ozone, nitrogen dioxide rapidly reacts with acetanilides ortho-selectively at low temperatures, giving a high proportion of ortho-nitro derivatives in good yields.
