10331-57-4

Basic information

• Product Name: NICLOFOLAN
• Synonyms: NICLOFOLAN;Niclofoian;1'-biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-(;3,3'-dichloro-5,5'-dinitro-o,o'-biphenol;4,4'-dichloro-6,6'-dinitro-o,o'-biphenol;5,5'-dichloro-2,2'-dihydroxy-3,3'-dinitrobiphenyl;5,5'-dichloro-3,3'-dinitro(1,1'-biphenyl)-2,2'-diol;menichlopholan
• CAS NO: 10331-57-4
• Molecular Formula: C₁₂H₆Cl₂N₂O₆
• Molecular Weight: 345.09
• EINECS: 233-720-0
• Product Categories: API
• Mol File: 10331-57-4.mol

Chemical Properties

• Boiling Point: 251.5°C (rough estimate)
• Flash Point: 210.8°C
• Appearance: /
• Density: 1.8594 (rough estimate)
• Vapor Pressure: 8.03E-08mmHg at 25°C
• Refractive Index: 1.7350 (estimate)
• PKA: 4.34±0.40(Predicted)
• CAS DataBase Reference: NICLOFOLAN(CAS DataBase Reference)
• NIST Chemistry Reference: NICLOFOLAN(10331-57-4)
• EPA Substance Registry System: NICLOFOLAN(10331-57-4)

Safety Data

• Hazardous Substances Data: 10331-57-4(Hazardous Substances Data)

Usage

Uses

Used in Veterinary Medicine:
Niclofolan is used as an anthelmintic agent for treating parasitic infections in domestic animals. It is effective against a wide range of intestinal and tissue-dwelling parasites, such as roundworms, tapeworms, and flukes, by disrupting their energy metabolism and leading to their immobilization and death.
Used in Animal Health and Welfare:
Niclofolan is used to improve the health and welfare of domestic animals by eliminating parasites that can cause various health issues, including malnutrition, anemia, and organ damage. Its high safety margin and low toxicity make it a preferred choice for treating parasitic infections in animals.
However, due to potential environmental and human health hazards, the use of Niclofolan is subject to strict regulations in many countries. It is commonly administered orally or via injection to ensure effective treatment while minimizing the risk of adverse effects.

InChI:InChI=1/C12H6Cl2N2O6/c13-5-1-7(11(17)9(3-5)15(19)20)8-2-6(14)4-10(12(8)18)16(21)22/h1-4,17-18H

Upstream product

• 31113-52-7 2,2'-Dihydroxy-5,5'-dichlorobiphenyl 

Downstream Products

• 25706-45-0 3,3'-diaminobiphenyl-2,2'-diol 

Relevant articles and documents

3-(Ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium cation: A green alternative to tert-butyl nitrite for synthesis of nitro-group-containing arenes and drugs at room temperature

Due to their remarkable properties, task-specific ionic liquids have turned out to be progressively popular over the last few years in the field of green organic synthesis. Herein, for the first time, we report that a new task-specific nitrite-based ionic liquid such as 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imides (TS-N-IL) derived from biodegradable ethyl nicotinate indeed acted as an efficient and eco-friendly reagent for the synthesis of highly valuable nitroaromatic compounds and drugs including nitroxynil, tolcapone, niclofolan, flutamide, niclosamide and nitrazepam. The bridging of an ionic liquid with nitrite group not only increases the yield and rate of direct C[sbnd]N bond formation reaction but also allows easy product separation and recyclability of a byproduct. Nonvolatile nature, easy synthesis, merely stoichiometric need and mildness are a portion of the extra focal points of TS-N-IL while contrasted with tert-butyl nitrite an outstanding and highly-flammable reagent utilized largely in organic synthesis.