100-26-5

Basic information

• Product Name: 2,5-PYRIDINEDICARBOXYLIC ACID
• Synonyms: pyridine2,5-dicarboxylate;2,5-LUTIDINIC ACID;2,5-PYRIDINECARBOXYLIC ACID;2,5-PYRIDINEDICARBOXYLIC ACID;ISOCINCHOMERIC ACID;ISOCINCHOMERONIC ACID;RARECHEM AL BO 2394;PYRIDINE-2,5-DICARBOXYLIC ACID
• CAS NO: 100-26-5
• Molecular Formula: C₇H₅NO₄
• Molecular Weight: 167.12
• EINECS: 202-834-2
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycle-Pyridine series
• Mol File: 100-26-5.mol

Chemical Properties

• Melting Point: 242-247 °C (dec.)(lit.)
• Boiling Point: 295.67°C (rough estimate)
• Flash Point: 220.5 °C
• Appearance: Yellow to green/Fine Crystalline Powder
• Density: 1.5216 (rough estimate)
• Vapor Pressure: 1.48E-08mmHg at 25°C
• Refractive Index: 1.6280 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 1.2g/l
• PKA: 3.06±0.10(Predicted)
• Water Solubility: 1.237g/L(25 oC)
• Merck: 14,5159
• BRN: 131697
• CAS DataBase Reference: 2,5-PYRIDINEDICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-PYRIDINEDICARBOXYLIC ACID(100-26-5)
• EPA Substance Registry System: 2,5-PYRIDINEDICARBOXYLIC ACID(100-26-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 100-26-5(Hazardous Substances Data)

Usage

Chemical Properties

yellow to green fine crystalline powder

Uses

Different sources of media describe the Uses of 100-26-5 differently. You can refer to the following data:
1. Used in the preparation of new 2,5-pyridinedicarboxylic acids derivatives as antiviral agents.
2. 2,5-Pyridinedicarboxylic acid can be used:In the synthesis of diorganotin(IV) 2,5-pyridinedicarboxylates.In the preparation of three-dimensional coordination polymers of lanthanide 2,5-pyridinedicarboxylates by hydrothermal method.As an organocatalyst in the synthesis of 1,5-benzodiazepine derivatives via one pot three-component reaction.

Definition

ChEBI: A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 5.

Purification Methods

Crystallise it from H2O or dilute HCl. [Napoli J Inorg Nucl Chem 32 1907 1970, Beilstein 22 H 153, 22 I 533, 22 II 105, 22 III/IV 1632, 22/4 V 124.]

InChI:InChI=1/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)/p-2

Upstream product

• 104-90-5 5-ethyl-2-methyl-pyridine 
• 91-63-4 2-methylquinoline 
• 589-93-5 2,5-dimethylpyridine 
• 140-76-1 2-methyl-5-vinylpyridine 
• 7446-08-4 selenium(IV) oxide 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 7732-18-5 water 
• 122-05-4 2,5-pyrazinedicarboxylic acid 
• 2050-89-7 3,3'-diaminobiphenyl 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 110-86-1 pyridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 881-86-7 dimethyl 2,5-pyridine dicarboxylate 
• 136-45-8 dipropyl pyridine-2,5-dicarboxylate 
• 70136-02-6 octyl nicotinate 
• 5552-44-3 ethyl 2,5-pyridinedicarboxylate 
• 102014-92-6 (+/-)-Nicotinsaeure-sec-butylester] 
• 59-67-6 nicotinic acid 
• 19490-92-7 1-phenyl-1-(pyridin-2-yl)ethanol 
• 6938-06-3 n-butyl nicotinate 
• 5620-35-9 pyridine-2,5-dicarboxylic acid dichloride 
• 110-86-1 pyridine 
• 386252-91-1 pyridine-2,5-dicarboxylic acid dipentafluorophenylester 
• 17874-76-9 6-(methoxycarbonyl)nicotinic acid 
• 17874-78-1 6-ethoxycarbonylpyridine-3-carboxylic acid 

Relevant articles and documents

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The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.

Stabilized radiolabelled compounds

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