- A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives
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The enantioselective organocatalytic reduction of aryl-substituted nitroenamines was successfully performed under continuous-flow conditions. After a preliminary screening with a 10-μL microreactor, to establish the best reaction conditions, the reduction was scaled up in a 0.5-mL mesoreactor, without appreciable loss of enantioselectivity, that remained constantly higher than 90%. The in-flow nitro reduction was also accomplished, either by Raney nickel catalyzed hydrogenation or by a metal-free methodology based on the use of the very inexpensive and readily available reducing agent trichlorosilane. The final aim is to develop a two-step, continuous-flow process for the stereoselective, metal-free, catalytic synthesis of differently functionalized chiral 1,2-diamines.
- Pirola, Margherita,Compostella, Maria Elena,Raimondi, Laura,Puglisi, Alessandra,Benaglia, Maurizio
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p. 1430 - 1438
(2018/02/09)
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- A nitroaryloxy aromatic preparation method (by machine translation)
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The invention discloses a nitroaryloxy aromatic preparation method, comprises the following steps: a, will R1 CHO, R2 CH2 NO2 , Catalyst and a polar organic solvent evenly, 0 °C -40 °C stirring for 6 hours -48 h
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Paragraph 0223; 0224; 0225; 0226; 0227; 0228; 0229-0244
(2017/05/23)
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- A amide preparation method of the compound
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The invention discloses a preparation method for an amide compound. The method comprises the steps of: a. taking R1CHO and R2CH2NO2, adding a catalyst and R3CN, carrying out stirring reaction for 24h-48h at 0DEG C-40DEG C to obtain a reaction liquid; and
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Paragraph 0228; 0229; 0230; 0231; 0232; 0233; 0234-0249
(2017/06/02)
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- Organocatalytic Enantioselective Transfer Hydrogenation of β-Amino Nitroolefins
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The asymmetric organocatalytic transfer hydrogenation of β-acylamino and β-tert-butyloxycarbonylamino nitroolefins has been successfully realised in excellent enantioselectivities and yields (up to >99% ee, 97% yield) with a simple thiourea catalyst and a Hantzsch ester as hydrogen source, giving a direct access to enantiomerically pure β-amino nitroalkanes. (Figure presented.).
- Ferraro, Antonino,Bernardi, Luca,Fochi, Mariafrancesca
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p. 1561 - 1565
(2016/10/13)
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- One-pot protocol to synthesize N-(β-nitro)amides by tandem Henry/Ritter reaction
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A novel, efficient and atom economical one pot protocol for the synthesis of N-(β-nitro)amides has been described by combining the Henry reaction with the Ritter reaction. The designed products could be obtained from easily available aldehydes, nitroalkan
- Ai, Wensi,Shi, Ronghua,Zhu, Liyan,Jiang, Dehong,Ma, Xiaobo,Yuan, Jilan,Wang, Zhouyu
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p. 24044 - 24048
(2015/03/30)
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- An efficient way to synthesize N-(β-nitroalkyl) amides through ritter reaction
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An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through
- Shi, Ronghua,Ai, Wensi,He, Tao,Ma, Xiaobo,Qian, Shan,Wang, Zhouyu
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p. 720 - 726
(2016/03/25)
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- Nitroacetamidation of Styrenes
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Reaction of styrenes with nitronium tetrafluoroborate in acetonitrile affords good yields of products of nitroacetamidation.In all cases addition is highly regeoselective to give Markownikoff products.With trans-β-methylstyrene, conversion of the initial
- Bloom, A. Jon,Fleischmann, Martin,Mellor, John M.
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p. 2357 - 2362
(2007/10/02)
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