Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones
A series of novel triazol-3-ones has been synthesized, and their in vitro and in vivo antifungal properties are reported. Traconazole. which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.
Heeres,Backx,Van Cutsem
p. 894 - 900
(2007/10/02)
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2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3
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