- A Novel, Base-induced Fragmentation of Hantzsch-type 4-Aryl-1,4-dihydropyridines
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Hantzsch-type 1,4-dihydropyridine derivatives substituted with highly electron-deficient aryl groups in the 4-position, on treatment with a variety of basic reagents in non-hydroxylic solvents, undergo an unexpected and ready scission of the inter-ring bond to give the corresponding 4-unsubstituted pyridine and an arene derived from the original 4-substituent.The scope of the reaction has been investigated and possible mechanisms are discussed.
- McInally, Thomas,Tinker, Alan C.
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p. 1837 - 1844
(2007/10/02)
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- Antihypertensive 2-phenyl Hantzsch dihydropyridines
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There are described compounds of formula I, STR1 in which R1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted by one or more of the groups halogen, nitro, --CN, --OR9, --S(O)p R9/
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