- Feasible Approach to Tricyclic and Tetracyclic cyclododecanone
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2-Bromocyclododecanone was utilized as precursor to synthesize polyfused heterocyclic cyclododecane ring systems. Transformation of 2-bromocyclododecanone (5) with 1H-benzimidazole-2-thiole (6), benzo[d]thiazole-2-thiol (9), 2-naphthol (12), and thiophenol (15) afforded thiazolo[2,3-b]benzimidazole (8), thiazolo[2,3-b]benzothaizole derivative (11) naphtho[1,2-d]furan derivative (14) and 2-(phenylthio)cyclododecanone (16), respectively.
- Zoorob, Hanafi H.,Elsherbini, Mohamed S.,Hamama, Wafaa S.
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p. 941 - 944
(2016/05/19)
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- METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO
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Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.
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Page/Page column 65; 66
(2010/04/03)
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- VIRAL POLYMERASE INHIBITORS
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Compound of Formula I: wherein, R2, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase
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Page/Page column 97
(2009/04/25)
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- BICYCLIC MELANOCORIN-SPECIFIC COMPOUNDS
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Melanocortin receptor-specific bicyclic compounds having the structure (I) and stereoisomer and pharmaceutically acceptable salts thereof, where R1,R2,R3 X and z are as described in the specification, which are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.
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Page/Page column 29-32
(2010/02/13)
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- Process for dehydrating hydrous sodium Beta-naphtholate
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The present invention provides a process for dehydrating hydrous sodium β-naphtholate comprising: the step of heating the hydrous sodium β-naphtholate or a mixture of the hydrous sodium β-naphtholate and β-naphthol which comprises no more than 0.2 mole of β-naphthol per one mole of sodium β-naphtholate in a solvent at a temperature of 260-300°C under an inert gas. The process makes it possible to dehydrate hydrous sodium β-naphtholate thoroughly in a short time with less production of tarry components.
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Page/Page column 4; 5
(2010/02/10)
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- Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment
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A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.
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- Process for producing 2 hydroxy-naphthalene-3-carboxylic acid
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A process for producing 2-hydroxynaphthalene-3-carboxylic acid comprising reacting carbon dioxide with a homogeneous liquid mixture comprising an alkali metal salt of β-naphthol, β-naphthol and a specific alkylbenzene is disclosed.
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- Process for the manufacture of anhydrous alkali metal arylate solutions and separation of the arylates from alkali metal sulfite
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Anhydrous organic solutions of alkali metal arylates are prepared by dissolving an alkali metal arylate or reacting an arylhydroxy compound with alkali metal hydroxide in a ketone immiscible or incompletely miscible with water at room temperature and removing the water from the solution, if any, by azeotropic distillation with reflux.
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