- Method for preparing 8-fluoroquinoline and method for preparing 3-iodo-8-fluoroquinoline
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The invention provides a method for preparing 8-fluoroquinoline and a method for preparing 3-iodo-8-fluoroquinoline. Preparation of the 8-fluoroquinoline comprises the step of carrying out a ring-closure reaction between fluoroaniline and glycerin, and preparation of the 3-iodo-8-fluoroquinoline comprises the step of carrying out a substitution reaction among the prepared 8-fluoroquinoline, N-chlorosuccinimide and a metal iodide. The method has the characteristics that the raw materials are cheap and readily available, the cost is low, any special equipment is not needed, the various materialsare low in toxicity, safe, environmental-friendly, less in by-products and high in yield, and large-scale industrial production is easily realized.
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Paragraph 0073-0084
(2018/03/26)
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- COMBINATION OF CB2 LIGAND AND PARACETAMOL
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Combination of one or more CB2 modulators and paracetamol are useful of treating conditions which are mediated by the activity of CB2 receptors such as an immune disorder, an inflammatory disorder, pain, rheumatoid arthritis, multiple sclerosis, osteoarthritis, and osteoporosis.
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Page/Page column 211-212
(2008/12/04)
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- NOVEL QUINOLINE COMPOUNDS CAPABLE OF BINDING AT THE CB2 RECEPTOR
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The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which possess are capable of selectively modulating the cannabinoid 2 receptor and the use of such compounds or pharmaceutical compositions thereof in the tr
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Page/Page column 16-17
(2008/06/13)
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- NOVEL CHEMICAL PROCESS FOR THE SYNTHESIS OF QUINOLINE COMPOUNDS
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A novel, simplified and economic process is described for making 3-phenylsulphonyl quinolines with an amine group at position 8 of the quinoline ring system, including 3-phenylsulfonyl-8-piperazin-1-yl-quinoline in particular, in the absence of a palladiu
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Page/Page column 12-13
(2008/06/13)
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- 3-((HETERO)ARYLSULFONYL)-8-` (AMINOALKYL)OXY!QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS
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The present invention relates to novel quinoline derivatives such as compounds of the formula (I): and the use of such compounds or pharmaceutical compositions thereof in the treatment of CNS and other disorders.
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Page/Page column 12
(2010/02/14)
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- 3-ARYLSULFONYL-QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS
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The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which have antagonist potency for the 5-HT6 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of C
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Page/Page column 10
(2008/06/13)
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