- 2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF
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The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.
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Paragraph 0293; 0294; 0295; 0296
(2021/04/16)
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- CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2
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Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with EGFR and/or HER2 activity.
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Page/Page column 67-68
(2021/07/17)
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- NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF
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The present invention relates to inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
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Page/Page column 32
(2010/11/03)
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- BICYCLIC AMIDE DERIVATIVES
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Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).
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Page/Page column 12
(2008/06/13)
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- BICYCLO DERIVATIVE
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A novel bicyclo derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof, acts as an effective DPP-IV inhibitor: One example is (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidi
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Page/Page column 7
(2008/06/13)
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- Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
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A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and
- Yeh, Vince S.C.,Kurukulasuriya, Ravi,Madar, David,Patel, Jyoti R.,Fung, Steven,Monzon, Katina,Chiou, William,Wang, Jiahong,Jacobson, Peer,Sham, Hing L.,Link
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p. 5408 - 5413
(2007/10/03)
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- BICYCLOESTER DERIVATIVE
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SUMMARY Novel bicycloester derivatives and pharmaceutically acceptable salts thereof have high DPP-IV inhibitory activity. SOLVING MEANS The novel bicycloester derivatives are represented by the general formula (1): Pharmaceutically acceptable salts there
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Page/Page column 12
(2010/11/24)
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