- The synthesis of ethyl 2-[(2,2-dibenzoyl)ethenyl]amino-3- dimethylaminopropenoate and its application to the synthesis of fused 3- aminopyran-2-ones and 3-aminoazolo- and -azinopyrimidin-4(4H)-ones
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Ethyl 2-[(2,2-dibenzoyl)ethenyl]amino-3-dimethylaminopropenoate (3) was prepared from dibenzoylmethane (1) in two steps, and used as a reagent for preparation of fused substituted 3-aminopyranones 12-15 in over 90% yield, quinolizin-4-one 16 in over 79% y
- Sorsak, Gorazd,Grdadolnik, Simona Golic,Stanovnik, Branko
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- Synthesis of 4-aroyl-5-arylpyrazoles and 4-aroyl-3-arylpyrazoles via the reaction of enaminodiketones with substituted hydrazines
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Pyrazole is a five-membered heterocyclic compound and is one of the important heterocycles in the fields of medicine and pharmacology. Here, we demonstrate the reactivity of symmetrical enaminodiketones 8–14 with substituted hydrazines. When using alkylhy
- Choshi, Tominari,Hatae, Noriyuki,Hibino, Satoshi,Kotouge, Rika,Nishiyama, Takashi,Oikawa, Tsutomu,Ono, Kanako,Yamauchi, Akira
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- SUBSTITUTED ENAMINONES, THEIR DERIVATIVES AND USES THEREOF
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The invention relates to substituted enaminones of Formula (I) and their derivatives and the discovery that these compounds modulate the effect of γ-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be us
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Page/Page column 37-38
(2008/06/13)
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- Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. I. Synthesis of 1,5-Disubstituted 4-Acylpyrazoles
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Reaction of open-chain and cyclic sym-1,3-diones with N,N-dimethylformamide dimethyl acetal gave, generally in high yield, a series of sym-2-dimethylaminomethylene-1,3-diones which reacted with phenylhydrazine and methylhydrazine to afford, generally in satisfactory yield, a number of 1,5-disubstituted 4-acylpyrazoles.The applications and limits of this new pyrazole synthesis are presented and discussed.
- Schenone, Pietro,Mosti, Luisa,Menozzi, Giulia
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p. 1355 - 1361
(2007/10/02)
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