SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS
This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.
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Page/Page column 20
(2009/04/24)
Benzoylphenylurea sulfur analogues with potent antitumor activity
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was
Hallur, Gurulingappa,Jimeno, Antonio,Dalrymple, Susan,Zhu, Tao,Jung, M. Katherine,Hidalgo, Manuel,Isaacs, John T.,Sukumar, Saraswati,Hamel, Ernest,Khan, Saeed R.
p. 2357 - 2360
(2007/10/03)
DESIGN AND SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BONZOYLPHENYLURIA (BPU) SULFUR ANALOGS
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more
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Page/Page column 40
(2008/06/13)
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