- Synthesis and antidepressant-like action of 9-alkoxy-7H-furo[3,2-g]chromen- 7-ones in mice
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The present study describes the chemical synthesis and pharmacological evaluation of a series of 9-alkoxy-7H-furo[3,2-g]-chromen-7-ones. The pharmacological results of these compounds show that nine of them, given orally, reduced the immobility time in the forced swimming test. The results of the open-field test further confirmed that these compounds possessed an antidepressant-like effect. In the 5-hydroxytryptophan induced head-twitch test, 9-(3-chlorobenzyloxy)-7H-furo[3,2-g]chromen-7-one (3m, 40 mg/kg p.o.) significantly increased the cumulative number of head twitches. This finding suggested that the antidepressant-like profile seems to involve the serotonergic system as underlying mechanism. ECV · Editio Cantor Verlag.
- Deng, Xian-Qing,Wei, Cheng-Xi,Song, Ming-Xia,Quan, Zhe-Shan
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experimental part
p. 587 - 592
(2011/05/11)
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- Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study
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Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of 1a were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 μg/mL) than 1a (MIC = 6.25 μg/mL), and is even potent than the positive control metronidazole (MIC = 0.50 μg/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of 1a have also led to an outline of structure-activity relationship.
- Zhang, Bang-Le,Fan, Cheng-Qi,Dong, Lei,Wang, Fang-Dao,Yue, Jian-Min
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supporting information; experimental part
p. 5258 - 5264
(2011/01/04)
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- A Simple One-step Synthesis of Phenyl Ethers from Phenyl Acetates
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Phenyl acetates when refluxed with alkyl halides in acetone solution in the presence of a crown ether and anhydrous potassium carbonate undergo alkylation yielding phenyl ethers.
- Banerjee, Sunil K.,Gupta, Bishan D.,Singh, Kuber
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p. 815 - 816
(2007/10/02)
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