- INHIBITORS OF HISTONE DEACETYLASE
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This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI)) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
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Paragraph 0302
(2016/04/26)
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- Electrochemical Cyclodimerization of Alkylidenemalonates
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Electrolysis of dimethyl alkylidenemalonates RCH=C(COOMe)2 (R=n-Alk, Ph) in an undivided cell in MeOH in the presence of alkali metal halide as mediator, leads to the formation of cyclic dimers, i.e., 3,4-disubstituted 1,1,2,2-cyclobutanetetracarboxylates.The reaction proceeds via the reductive coupling of two substrate molecules at cathode and the cyclization of a hydrodimer dianion by its interaction with an active form of a mediator, an anode-generated halogen.
- Elinson, Michail N.,Feducovich, Sergey K.,Zakharenkov, Alexandre A.,Ugrak, Bogdan I.,Nikishin, Gennady I.,et al.
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p. 5035 - 5046
(2007/10/02)
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- ELECTROREDUCTIVE CYCLIZATION. A COMPARISON OF THE ELECTROCHEMICAL AND ANALOGOUS CHEMICAL (MIRC) REACTION
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Several examples which illustrate the contrasting and complementary aspects of electroreductive cyclization and MIRC reactions are presented.A brief mechanistic discussion of the electrochemical reaction is given and two examples of the use of an electroc
- Nugent, Sean T.,Baizer, Manuel M.,Little, R. Daniel
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p. 1339 - 1342
(2007/10/02)
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