- Synthesis of deuterium-labelled standards of (±)-DOM and (±)-MMDA
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This study describes the synthesis of deuterium-labelled (±)-4-methyl-2,5-dimethoxyamphetamine (DOM) and (+)-l-(7-methoxy-l,3- benzodioxol-5-yl)propan-2-amine (MMDA). The isotopically labelled compounds are potentially used as internal standards in gas chromatography-mass spectrometry (GC-MS) assays. Copyright
- Shaikh, Ajam C.,Wang, Yu-Yun,Chen, Chinpiao
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p. 660 - 665
(2008/02/10)
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- Aromatic Hydroxylation. Hydroxybenzaldehydes from Bromobenzaldehydes via Reaction of in Situ Generated, Lithiated α-Morpholinobenzyl Alkoxides with Nitrobenzene
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A general method for the one-step conversion of bromobenzaldehydes to the corresponding hydroxybenzaldehydes has been developed.The method involves in situ protection of the aldehyde function of the bromobenzaldehyde as its lithium morpholinoalkoxide, followed by lithium-bromine exchange, reaction with nitrobenzene at -75 deg C, and a subsequent acidic workup.The method has been applied to the synthesis of 4,5-dimethoxy-3-hydroxy- (1a), 3,5-dimethoxy-2-hydroxy- (2a), 3,5-bis(benzyloxy)-2-hydroxy- (2b), 3,4-dimethoxy-2-hydroxy- (14), 3-hydroxy-4,5-(methylenedioxy)- (16), and 4,5-dimethoxy-2-hydroxybenzaldehydes (18) from the bromobenzaldehydes 4, 12a, 12b, 13, 15, and 17, respectively.
- Sinhababu, Achintya K.,Borchardt, Ronald T.
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p. 1941 - 1944
(2007/10/02)
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