cas 80653-66-3, THIAZOLE-4-CARBOTHIOIC ACID AMIDE | Articles data ｜lookchem

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80653-66-3

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Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors
Inspired by the thiazole-thiazoline cap group in natural product largazole, a series of structurally simplified bisthiazole-based histone deacetylase inhibitors were prepared and evaluated. Compound 8f was evaluated in vivo in an experimental autoimmune encephalomyelitis (EAE) model and found to be orally efficacious in ameliorating clinical symptoms of EAE mice.
Chen, Fei,Chai, Hui,Su, Ming-Bo,Zhang, Yang-Ming,Li, Jia,Xie, Xin,Nan, Fa-Jun
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p. 628 - 633
(2014/07/07)

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Chemical Properties

Melting Point: 195-197℃ (ethanol )
Boiling Point: 295.3±32.0 °C(Predicted)
Density: 1.461±0.06 g/cm3 (20 ºC 760 Torr)
Refractive Index: 1.718
PKA: 11.87±0.29(Predicted)
PSA: 99.24000
LogP: 1.47760

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