- Guanidine compound for preventing and treating chronic pain medication (by machine translation)
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The invention relates to a guanidine compound as shown in general formula (I) as a guanidine compound for preventing and treating chronic pain disease. A pharmaceutically acceptable salt thereof, a prodrug thereof, a solvate thereof, a deuterated substanc
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Paragraph 0322-0326
(2020/08/27)
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- BENZOFUROPYRAZOLE DERIVATIVE
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PROBLEM TO BE SOLVED: To provide a novel material having HIF inhibitory activity. SOLUTION: The present invention provides a compound represented by the following general formula (I) [where R1, R2, R3, and R4 each represent a hydrogen atom, a methoxy group, an ethoxy group, a hydroxy group, an N-morpholylurea group, or an N-(4-aminophenyl) urea group, or adjacent ones of them bind together to form an alkylenedioxy group; R5, R6, R7, R8, and R9 each represent a hydrogen atom, a methoxy group, a hydroxy group, a methoxy carbonyl group, a carboxyl group, an isopropyl group, or an isobutoxy group, or adjacent ones of them bind together to form an alkylenedioxy group]. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
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Paragraph 0052
(2017/02/24)
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- Exploring Epidermal Growth Factor Receptor (EGFR) inhibitor features: The role of fused dioxygenated rings on the quinazoline scaffold
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A number of dioxolane, dioxane, and dioxepine quinazoline derivatives have been synthetized, and evaluated as EGFR inhibitors. Their cytotoxic activity has been tested against two cell, lines overexpressing and not expressing EGFR. Most derivatives were a
- Chilin, Adriana,Conconi, Maria Teresa,Marzaro, Giovanni,Guiotto, Adriano,Urbani, Luca,Tonus, Francesca,Parnigotto, Pierpaolo
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supporting information; experimental part
p. 1862 - 1866
(2010/08/06)
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- Synthesis and crystal structure of 3, 4-dihydro-7-acetamido-2H-1,5-benzodioxepine
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The synthesis of 3,4-dihydro-7-acetamido-2H-1,5-benzodioxepin III is achieved starting from 3,4-dihydro-7-nitro-benzodioxepin II. The new acetamid prepared is characterized by spectroscopic technics, IR; UV; 1H-NMR; 13C-NMR; mass spectrometry and by XR diffraction. A monocrystal from the product is selected and its crystal structure resolved. The solid crystallizes in orthorhombic system with space group Pcab. The crystal cohesion is assumed by hydrogen bonds and Vander-Waals interactions.
- Ouerghui, Abid,Hlel, Faouzi,Meganem, Faouzi
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p. 125 - 130
(2007/10/03)
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- Influence of the Heterocyclic Side Ring on Orientation During Nitrations of 1,2-Alkylenedioxy-annelated Benzenes and Their Mononitro Derivatives
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Nitration of 1,2-alkylenedioxybenzenes 1 furnished the respective nitro derivatives 3 and 4 in the relative ratios: 4a:3a/100:trace, 4b:3b/98:2.4, 4c:3c/86:14, 4e:3e/91:9, 4f:3f/99:1.3.Nitration of 4 gave 5a:6a:8a/0:0:100, 5b:6b:8b/7.7:3.2:89, 5c:6c:8c/23:12:65, 5d:6d:8d/14:74:12, 5e:6e:8e/27:18:55 and 5f:6f:8f/23:7.0:70.Nitration of the isomeric 3 afforded the dinitroproducts 5, 6 and 7 in the following relative ratios: 5a:6a:7a/92:8:0, 5b:6b:7b/80:20:0, 5c:6c:7c/69:20:11, 5d:6d:7d/45:19:36, 5e:6e:7e/37:57:5.9 and 5f:6f:7f/64:36:0.Nitration of 3-nitro-1,2-dimethoxybenzene (9) furnished: 10:11/63:37.Orientation as a function of the h eterocyclic ring-size is discussed.
- Takakis, Ioannis M.,Hadjimihalakis, Phaedon M.
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p. 625 - 634
(2007/10/02)
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