- Preparation method of 2, 6-dichlorophenylboronic acid
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The invention discloses a preparation method of 2, 6dichlorophenylboronic acid, which belongs to the technical field of fine processing, and mainly comprises the following steps: adding magnesium chips into 2bromo 1, 3dichlorobenzene used as a raw material to prepare a Grignard reagent, reacting with trialkyl borate, and carrying out acidic hydrolysis to obtain a 2, 6dichlorophenylboronic acid crude product; and finally, recrystallizing and purifying to obtain pure 2, 6-dichlorophenylboronic acid. The preparation method is simple, raw materials are easy to obtain, and the method is suitable for large-scale industrial production.
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Paragraph 0035-0039
(2020/12/29)
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- 2,6-dichlorophenylboronic acid synthesis method
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The invention discloses a 2,6-dichlorophenylboronic acid synthesis method, which comprises: (1) mixing bromobenzene and tetrahydrofuran under nitrogen protection, adding n-butyllithium in a dropwise maner, and carrying out a thernal insulation reaction af
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Paragraph 0050-0055
(2019/01/14)
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- Moisture-Tolerant Frustrated Lewis Pair Catalyst for Hydrogenation of Aldehydes and Ketones
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In this paper, we report on the development of a bench-stable borane for frustrated Lewis pair catalyzed reduction of aldehydes, ketones, and enones. The deliberate fine-tuning of structural and electronic parameters of Lewis acid component and the choice of Lewis base provided for the first time, a moisture-tolerant FLP catalyst. Related NMR and DFT studies underpinned the unique behavior of this FLP catalyst and gave insight into the catalytic activity of the resulting FLP catalyst.
- Gy?m?re, ádám,Bakos, Mária,F?ldes, Tamás,Pápai, Imre,Domján, Attila,Soós, Tibor
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p. 5366 - 5372
(2015/09/15)
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- Inhibitors of α4 mediated cell adhesion
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The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, —O-(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur, W is oxygen, sulfur, —CH═CH—, —NH— or —N═CH—; R1, R2and R3are the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; R4is tetrazolyl, carboxyl group, amide or ester; R5is hydrogen, nitro, amino, hydroxyl, lower alkanoyl, lower alkyl etc.; R6is selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstituted benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.
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