- Method for preparing prednicarbate intermediate
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The invention relates to a method for preparing a prednicarbate key intermediate (a compound of a formula III shown in the description). According to the method, a compound of a formula II shown in the description is adopted as a raw material, water and ethanol are adopted as solvents, and the compound of the formula III shown in the description is prepared through a hydrolysis reaction under theacid condition. Compared with the prior art, the conversion rate of the compound of the formula II shown in the description is increased, problems that the compound of the formula III shown in the description is not easy to separate, purify, crystallize and the like can be solved, the compound of the formula III with high purity can be conveniently and rapidly prepared, and the method is applicable to industrial production.
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Paragraph 0043-0045
(2020/02/07)
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- Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
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Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
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- Composition for the topical treatment of poison ivy and other forms of contact dermatitis
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Composition for topical administration comprising (a) a corticosteroid, and (b) a drying agent.
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- Synthesis of prednicarbate, an unhalogenated topical antiinflammatory derivative of prednisolone-17-ethylcarbonate-21-propionate
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The synthesis of prednisolone-17-ethylcarbonate-21-propio-nate (prednicarbate, Hoe 777) passing the intermediate products prednisolone 17,12-diethylorthocarbonate and prednisolone-17-ethylcarbonate as well as some physico-chemical properties and spectroscopic data of especially the 1H-NMR- and MS-spectrum, are reported. Prednicarbate has an optimal split of topical/systemic antiinflammatory activity.
- Stache,Fritsch,Rupp,Hitzel,Fehlhaber
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p. 1753 - 1757
(2007/10/02)
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