- Synthesis and characterization of polyquinolines for light-emitting diodes
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A novel light-emitting polymer containing both a highly electron- affinitive segment, biquinoline, and a good hole transporting segment, dialkoxyphenylenevinylene, was synthesized and characterized. This polymer possessed excellent film-forming properties
- Liu, Michelle S.,Liu, Yunqi,Urian, R. Craig,Ma, Hong,Jen, Alex K.-Y.
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- Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1
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The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), mediates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported.
- Aliouane, Lucie,Chao, Sovy,Brizuela, Leyre,Pfund, Emmanuel,Cuvillier, Olivier,Jean, Ludovic,Renard, Pierre-Yves,Lequeux, Thierry
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p. 4955 - 4960
(2014/10/16)
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- Synthesis and stability of 2-(1,1-difluoroalkyl) thiophenes and related 1,1-difluoroalkyl benzenes: Fluorinated building blocks for liquid crystal synthesis
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The synthesis of a series of 2-(1,1-difluoroalkyl) thiophenes, including some biphenylthienyl liquid crystalline materials, was examined using a variety of fluorination approaches. For comparison purposes, a series of 1,1-difluoroalkyl benzene analogs were also prepared. The direct fluorodeoxygenation of alkyl thienyl ketones and alkyl phenyl ketones using various aminofluorosulfuranes proceeded in only moderate to poor yields. In contrast, fluorodesulfurization of the corresponding 1,3-dithiolanes using NOBF4/PPHF cleanly afforded the desired 2-(1,1-difluoroalkyl) thiophenes (and analogous 1,1-difluoroalkyl benzenes) in high yields. Fluorodesulfurization of 2-alkyl-2-thienyl-1,3-dithiolanes using NBS (or DBH)/PPHF was complicated by competing ring and/or side chain bromination pathways. These problems were avoided when using NIS/PPHF. Although the various 1,1-difluoroalkyl arene products were sensitive to hydrolytic decomposition on prolonged exposure to silica, the purified products proved quite stable and were well suited for use as building blocks for liquid crystal synthesis.
- Kiryanov, Andre A.,Seed, Alexander J.,Sampson, Paul
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p. 5757 - 5767
(2007/10/03)
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- Highly efficient chromium-catalyzed oxidation of secondary benzylic alcohols by aqueous 70% tert-butyl hydroperoxide
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The oxidation of secondary benzylic alcohols to ketones by the chromium(VI) oxide/tert-butyl hydroperoxide system is compatible with the presence of methyl, halide, methoxy, acetoxy or nitro substituents on the aryl group and of an unsaturation on the alkyl side chain. Benzyl alcohol led to a mixture of benzaldehyde and benzoic acid.
- Muzart,N'Ait Ajjou
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p. 785 - 787
(2007/10/02)
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