Copper-Mediated Fluorination of Aryl Trisiloxanes with Nucleophilic Fluoride
A method for the nucleophilic fluorination of heptamethyl aryl trisiloxanes to form fluoroarenes is reported. The reaction proceeds in the presence of Cu(OTf)2 and KHF2 as the fluoride source under mild conditions for a broad range of heptamethyltrisiloxyarenes with high functional group tolerance. The combination of this method with the silylation of aryl C?H bonds enables the regioselective fluorination of non-activated arenes controlled by steric effects following a two-step protocol.
Dorel, Ruth,Boehm, Philip,Schwinger, Daniel P.,Hartwig, John F.
supporting information
p. 1759 - 1762
(2020/02/05)
Macrocyclic compounds and methods for their production
There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.
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Page/Page column 39; 40
(2015/11/10)
Sanglifehrin Derivatives and Methods for Their Production
There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.
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Paragraph 0157; 0158
(2014/04/03)
Novel Dosage Form
There is provided inter alia a pharmaceutical dosage form for oral administration comprising a sanglifehrin as active ingredient in which the sanglifehrin active ingredient is protected from acid degradation in the stomach environment following oral admin
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Paragraph 0262; 0263
(2014/09/03)
NOVEL DOSAGE FORM
There is provided inter alia apharmaceutical dosage form fororal administration comprising a sanglifehrin as active ingredient in which the sanglifehrin active ingredient is protected from acid degradation in the stomach environment following oral adminis
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Page/Page column 63
(2013/05/21)
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