- FLAVOR AND FRAGRANCE COMPOUNDS
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Acetaldehyde precursors useful in flavors and fragrances, especially in consumable products, are according to formula (I), wherein R1 and R2 are selected such that both are -CH2CH3, or both are linear, branched or cyclic alkyl, aryl, alcohol or sugar residues, and n=1-10, with the proviso that, when R1 and R2 are selected such that both are -CH2CH3, n=1, 2, 3 or 4. The precursors overcome many of the disadvantages of present sources of acetaldehyde in consumable products.
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- Methods of treating cytokine mediated diseases
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Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein.
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- Aromatic heterocyclic compounds as antiinflammatory agents
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Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
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- Synthesis of 2-[1-(2,5-dimethylphenyl)ethylsulfonyl]pyridine-1-oxide herbicide and intermediates therefor
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Hydrogen chloride is passed into p-xylene and acetaldehyde to form bis-1-chloroethyl ether; the latter is converted to 2-(1-chloroethyl)-1,4-dimethylbenzene by the action of sulfuric acid and hydrogen chloride. Alkali metal hydrogen sulfide in aqueous methanol or ethanol converts the 2-(1-chloroethyl)-1,4-dimethylbenzene to alpha,2,5-trimethylbenzenemethanethiol; the sodium salt of the latter reacted with 2-chloropyridine-1-oxide yields 2-[1-(2,5-dimethylphenyl)ethylthio]pyridine-1-oxide which is then oxidized with hydrogen peroxide and alkali metal tungstate or tungstic acid to form 2-[1-(2,5-dimethylphenyl)ethylsulfonyl]pyridine-1-oxide.
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