Bifunctional Chelating Agents. Part 2. Synthesis of 1-(2-Carboxyethyl)ethylenediaminetetra-acetic Acid by Ring Cleavage of a Substituted Imidazole
The synthesis of 1-(2-carboxyethyl)ethylenediaminetetra-acetic acid, a new bifunctional analogue of ethylenediaminetetra-acetic acid (EDTA) is described.This is carried out via ring-opening benzoylation of ethyl imidazol-4-ylpropanoate, hydrogenation and hydrolysis to 4,5-diaminovaleric acid (DL-γ-ornithine) dihydrochloride, and subsequent alkylation.
Altman, Janina,Shoef, Nurit,Wilchek, Meir,Warshawsky, Abraham
p. 59 - 62
(2007/10/02)
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