- 2, 3, 5-trifluoro-4-difluoro (3, 4, 5-trifluoro-density) methyl-benzene formaldehyde and its synthetic method and in the preparation of the application of the liquid crystal compound
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The invention provides 2,3,5-trifluoro-4-difluoro(3,4,5-trifluorophenylol)methyl-benzaldehyde (a compound of formula 8), and its preparation method. The compound can be used to synthesize a compound with the structure represented by formula I as an interm
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Paragraph 0064-0066
(2017/02/28)
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- General synthetic pathway to oxygenated 3-methylbenz[g]isoquinoline- 5,10-diones
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The synthesis of naturally occurring dioxygenated and trioxygenated 3- methylbenz[g]isoquinoline-5,10-diones has been accomplished. The critical step involved regioselective additions of di- or trifluorobenzylzinc bromides to activated methyl 6-methylnicotinate. Aromatizations of the resultant dihydropyridines followed by hydrolysis led to the corresponding benzylpyridinecarboxylic acids which on annulative-oxidations led to the respective difluoro- or trifluorobenz[g]isoquinoline-5,10-diones. Displacements of fluorides by methoxide led to the di- or trimethoxy analogues which on selective demethylations led to bostrycoidin, 8-O- methylbostrycoidin, tolypocladin, 5-deoxybostrycoidin or 5-deoxy-6-O-methyl- bostrycoidin. The synthesis of isobostrycoidin and isotolypocladin has also been accomplished.
- Krapcho, A. Paul,Waterhouse, David J.
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p. 737 - 750
(2007/10/03)
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