- Regioselective synthesis of phenoxathiin derivatives under transition-metal-free conditions
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A simple and efficient method was developed for the synthesis of phenoxathiin derivatives. A range of 1,2-dihaloarenes or 1-halo-2-nitroarenes reacted with 2-sulfanylphenol to give the desired products in good-to-excellent yields. It is intriguing that 1-halo-2-nitroarenes containing electron-donating groups worked well as substrates in this reaction. Georg Thieme Verlag Stuttgart - New York.
- Hu, Fangdong,Zhao, Xin,Li, Yanqiu,Feng, Lei,Ma, Chen
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p. 966 - 970
(2013/05/09)
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- Synthesis of Some Heterocyclic Skeletons via Organoiron Complexes. Crystal and Molecular Structure of (5a,6,7,8,9,9a-η6-1,4-Benzoxathiinopyridine)(η5-cyclopentadienyl)iron Hexafluorophosphate
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Synthesis of the heterocyclic skeletons of some biologically active compounds from (η6-dichlorobenzene)(η5-cyclopentadienyl)iron hexafluorophosphate in a two step procedure is described.Cyclopentadienyliron hexafluorophosphate complexes of 1,4-benzodioxinopyridine, 1,4-benzoxathiinopyridine, 10H-pyridobenzoxazine, benzonaphthodioxin, 4-methylbenzobenzopyran-2-onedioxin and benzoanthracen-9,10-dionodioxin were isolated and characterized.Upon pyrolytic sublimation of these complexes the free heterocycles were obtained and characterized. (η6-1,4-Benzoxathiinopyridine)(η5-cyclopentadienyl)iron hexafluorophosphate crystalizes in the orthorhombic system, space group Pbca; the dihedral angle between the planes of outerrings was found to be 176.6 (1).
- Sutherland, Ronald G.,Piorko, Adam,Lee, Choi Chuck,Simonsen, Stanley H.,Lynch, Vincent M.
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p. 1911 - 1916
(2007/10/02)
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- Central Nervous System Activity of 7-Substituted 1-Azaphenoxathiin Analogues and Their Oxidation Products
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A number of 7-substituted 1-azaphenoxathiins and their sulfone oxidation products have been synthesized and screened for central nervous system activity.Some of the compounds have antidepressant activity, with the most active 7-(trifluoromethyl)-1-azaphenoxathiin 10,10-dioxide (8), having similar potency to imipramine.
- Elliott, Arthur J.,Eisenstein, Norman,Iorio, Louis C.
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p. 333 - 335
(2007/10/02)
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