- Effect of 4(2)-Octylaminopyridine Distribution in a Water (HCl)/Chloroform System on the Extraction of Metal Ions from Chloride Solutions
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Abstract: Distributions of 4(2)-octylaminopyridines (4(2)-OAPs) as extractants in an H2O(HCl)/CHCl3 system were studied by UV and IR spectroscopy and potentiometry. The ionization constant of monoprotonated 4-OAP, the logarithmic distribution constant of 4-OAP and its chloride, and the logarithmic extraction constant of hydrochloric acid were calculated. These values were compared with those for 2-OAP. The isotherm (20 ± 2°C) of HCl extraction with 0.1 M 4-OAP in chloroform is given. The difference in the extraction chemistry of hydrochloric acid with 2- and 4-OAPs and specific application features of these reagents for extraction of metals from chloride solutions are discussed.
- Borshch,Ageeva,Frolova, A. Yu.
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- Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives
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Novel tris(4-alkylaminopyridin-1-ium) trichlorides with alkylcyanuric spacer were synthesized by quaternization of 4-alkylaminopyridines with tris(2-chloroethyl) cyanurate. The obtained compounds were evaluated for microbiological activity against five pathogenic bacterial strains (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Acinobacter baumannii, Pseudomonas aeruginosa). The results indicate the presence of pronounced antibacterial properties in this group of compounds.
- Derkach, Yana V.,Detusheva, Elena V.,Egorov, Mikhail P.,Frolov, Nikita A.,Minaeva, Alexandra P.,Vereshchagin, Anatoly N.
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p. 368 - 369
(2021/06/07)
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- A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions
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A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.
- Huang, Binbin,Guo, Lin,Xia, Wujiong
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supporting information
p. 2095 - 2103
(2021/03/26)
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- PROCESS FOR THE SYNTHESIS OF N-ALKYL-4-PYRIDINAMINES
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The present invention relates to an improved process for the synthesis of N-alkyl-4-pyridinamines comprising the catalytic hydrogenation of a precursor compound which is carried out in the presence of an acid.
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Page/Page column 10-11
(2021/01/29)
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- Method of synthesizing 4-alkylamino pyridine in mild condition
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The invention discloses a method of synthesizing 4-alkylamino pyridine in a mild condition, and belongs to the technical field of organic synthesis. The method comprises performing a nucleophilic substitution reaction on 4-chloropyridine hydrochloride with alkyl amine in the presence of an inhibitor to prepare the 4-alkylamino pyridine, wherein the reaction temperature is in a range of 30-150 DEG C, the reaction time is in a range of 1-10 hours, the inhibitor is a fluoride salt, and the mass ratio of the inhibitor to the 4-chloropyridine hydrochloride is (0.1-1):1. In order to solve the problem of production safety hidden danger caused by a sharp rise of temperature in such kind of nucleophilic substitution reactions, the method provided by the invention introduces the inhibitor to control the reaction speed. With the addition of the inhibitor, the rise of the reaction temperature is effectively controlled, the reaction temperature and reaction speed are reduced to a controllable range, and thus the method provides possibility for safe production and is suitable for large-scale production. In addition, the synthetic reaction has only one step, the yield can reach 80%, and compared with the products of nucleophilic substitution reactions with no inhibitors, the product purity is increased and can reach 99% or more.
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Paragraph 0018
(2018/01/17)
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- The improved method for preparing octenidine dihydrochloride and the method for preparing a pharmaceutical composition containing the octenidine dihydrochloride
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The present invention relates to an improved novel method for preparing octenidine dihydrochloride which has chemical name 1 of 10-bis-[4-(octylamino)-1-pyridinium]-decane dichloride, is represented by chemical formula, C_36H_64Cl_2N_4, and has MW of 623.84 and MP of 215~217anddeg;C. The octenidine dihydrochloride is used widely in hospitals and in the general public as an agent for skin sterilization and disinfection. The method according to the present invention can reduce the preparation cost and decrease impurities generated during the preparation process. In addition, the present invention relates to a novel composite and formulation for use in skin sterilization and disinfection, which comprise octenidine dihydrochloride. When using the sterilizing and disinfecting agent according to the present invention, it is possible to provide a method for preparing a safe sterilizing and disinfecting agent which can prevent skin infection, respiratory infection, and hospital infection that becomes a problem recently in relation to a sterilizing and disinfecting agent used in hospitals.COPYRIGHT KIPO 2017
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Paragraph 0099; 0100
(2017/05/12)
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- Highly reactive, general and long-lived catalysts for palladium-catalyzed amination of heteroaryl and aryl chlorides, bromides, and iodides: Scope and structure-activity relationships
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We describe a systematic study of the scope and relationship between ligand structure and activity for a highly efficient and selective class of catalysts containing sterically hindered chelating alkylphosphines for the amination of heteroaryl and aryl chlorides, bromides, and iodides. In the presence of this catalyst, aryl and heteroaryl chlorides, bromides, and iodides react with many primary amines in high yields with part-per-million quantities of palladium precursor and ligand. Many reactions of primary amines with both heteroaryl and aryl chlorides, bromides, and iodides occur to completion with 0.0005-0.05 mol % catalyst. A comparison of the reactivity of this catalyst for the coupling of primary amines at these loadings is made with catalysts generated from hindered monophosphines and carbenes, and these data illustrate the benefits of chelation. Studies on structural variants of the most active catalyst indicate that a rigid backbone in the bidentate structure, strong electron donation, and severe hindrance all contribute to its high reactivity. Thus, these complexes constitute a fourth-generation catalyst for the amination of aryl halides, whose activity complements catalysts based on monophosphines and carbenes.
- Shen, Qilong,Ogata, Tokutaro,Hartwig, John F.
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p. 6586 - 6596
(2008/12/22)
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- [(CyPF-Bu)PdCI2]: An air-stable, one-component, highly efficient catalyst for amination of heteroaryl and aryl halides
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(Chemical Equation Presented) An air- and moisture-stable palladium catalyst, [(CyPF-1Bu)PdCI2] (1), for coupling of heteroaryl chlorides, bromides, and iodides with a variety of primary amines is described. Most of these reactions occurred in high yield with 0.001-0.05 mol % catalyst loading. The reactions tolerated a wide range of functional groups.
- Shen, Qilong,Hartwig, John F.
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supporting information; experimental part
p. 4109 - 4112
(2009/05/27)
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- Highly reactive, general, and long-lived catalysts for coupling heteroaryl and aryl chlorides with primary nitrogen nucleophiles
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Resisting pathways for decomposition followed by palladium complexes of monodentate ligands is one characteristic of the highly reactive but long-lived catalyst generated from the Josiphos ligand L and palladium. It catalyzes under mild conditions the coupling of primary amines with chloropyridines and chloroarenes in high yield with low catalyst loadings (see scheme).
- Shen, Qilong,Shekhar, Shashank,Stambuli, James P.,Hartwig, John F.
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p. 1371 - 1375
(2007/10/03)
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- A new facile method for the synthesis of 4-dialkylaminopyridine derivatives by high-pressure-promoted amination of 4-chloropyridine
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A new method for synthesizing 4-(di)alkylaminopyridine derivatives in high yield was established by the high-pressure-promoted nucleophilic aromatic substitution of 4-chloropyridine with various primary/secondary amines.
- Kotsuki, Hiyoshizo,Sakai, Hiromitsu,Shinohara, Toshio
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p. 116 - 118
(2007/10/03)
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- Bispyridinamines: A New Class of Topical Antimicrobial Agents as Inhibitors of Dental Plaque
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A series of N,N'-polyalkylenebis has been prepared, and members have been evaluated as potential anti-dental plaque agents.From among the most active members of the series, one compound, N,N'-bis(1-octanamine) dihydrochloride, octenidine, was selected as a candidate for clinical study.
- Bailey, Denis M.,DeGrazia, C. George,Hoff, Stephanie J.,Schulenberg, Patsy L.,O'Connor, John R.,et al.
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p. 1457 - 1464
(2007/10/02)
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- Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes
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Bis-[4-(R-amino)-1-pyridinium]alkanes are prepared by reacting a 4-(R-amino)pyridine with an appropriate disubstituted alkane. The compounds are useful as antimicrobial agents. Certain species are also useful as dental plaque-preventive agents.
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