- Method for coproducing OIT and DCOIT
-
The invention discloses a method for coproducing OIT and DCOIT. The method comprises the following steps: adding a raw material N, N'-di-n-octyldithiodipropionamide or N-n-octylmercaptopropionamide and a solvent into a chlorination reaction kettle, introducing chlorine, and carrying out solid-liquid separation on the material in the reaction kettle after the reaction is finished; distilling the obtained mother liquor under reduced pressure, and reserving kettle residues for later use; transferring the obtained filter cake to a neutralization kettle, adding a solvent and alkali liquor for neutralization and liquid separation to obtain an organic layer; carrying out water washing, desolventizing and filtering part on the organic layer to obtain the OIT finished product; carrying out azeotropic dehydration on the other part of the organic layer, combining with the kettle residues, introducing chlorine for chlorination, adding an alkali liquor into reaction liquid obtained after the reaction is finished for neutralization, and filtering; and recrystallizing the obtained filter cake, and leaching and drying the obtained solid to obtain the DCOIT finished product. According to the invention, the production efficiency is improved, the product quality is improved, and the method is an efficient and environment-friendly production method.
- -
-
Paragraph 0044-0047
(2021/01/11)
-
- Preparation method of 4, 5-dichloro-2-n-octyl-3-isothiazolinone
-
The invention discloses a preparation method of 4, 5-dichloro-2-n-octyl-3-isothiazolinone. The preparation method comprises the following steps: 1) carrying out a reaction on dimethyl dithiodipropionate and n-octylamine to obtain 3, 3'-dithiodioctyl propionamide; and 2) carrying out a reaction on the 3, 3'-dithio dioctyl propionamide and phosphorus oxychloride, so as to obtain the 4, 5-dichloro-2-n-octyl-3-isothiazolinone. The preparation method of the 4, 5-dichloro-2-n-octyl-3-isothiazolinone provided by the invention is simple, impurities are not introduced in the process, the product purity is high, the production is environment-friendly and safe, and the market application prospect is wide.
- -
-
Paragraph 0032-0033; 0035; 0036; 0038; 0039; 0041; 0042; ...
(2021/11/03)
-
- Preparation method of 3-isothiazolinone compound
-
The invention discloses a preparation method of a 3-isothiazolinone compound, which comprises the following steps of adding raw materials and a solvent into a reaction system, and stirring and mixing,adding a dehydrating agent into the mixed solution, and stirring for reaction, introducing chlorine into the reaction system, stirring the reaction mixture for reaction, filtering and separating to obtain a product. According to the method, the chemical dehydrating agent is added into the reaction system to react with water or alcohol in the reaction system, so that water or alcohol in the systemis removed, side reaction caused by water or alcohol is avoided, the reaction yield is increased, and the economic benefit is remarkable.
- -
-
Paragraph 0030-0032; 0036-0039
(2020/12/31)
-
- A 4, 5 - dichloro - N - [...] thiazolinone preparation method
-
A preparation method of 4,5-dichloro-N-n-octyl isothiazolinone uses N,N- di-n-octyl-3,3-disulfide-di-propionamide as a raw material, and comprises the following steps: mixing N,N- di-n-octyl-3,3-disulfide-di-propionamide with a chloro solvent; adding a composite catalyst comprising metal chlorides, thiophene compounds and crown ether compounds; adding a chlorating agent at a low-temperature condition for closed-loop chlorination; carrying out separation and purification to obtain the 4,5-dichloro-N-n-octyl isothiazolinone. Tests show that the purity of the 4,5-dichloro-N-n-octyl isothiazolinone prepared according to the method can be higher than 98 percent; the product yield can be higher than 65 to 75 percent. Compared with the prior art, the method has the advantages that as the composite catalyst is adopted, the reaction time is short, the product cost is low, and the yield is high; the catalyst, the solvent as well as unreacted raw materials can be recycled, so that the requirements of environmental protection are met; the method is high in selectivity, mild in reaction, easy to control, stable in product quality, and high in yield, thereby being suitable for industrialized production.
- -
-
Paragraph 0013; 0027-0032
(2019/02/08)
-
- Preparation method of 2-n-octyl-4-bromo-5-chloro-3-isothiazolone
-
The invention discloses a preparation method of 2-n-octyl-4-bromo-5-chloro-3-isothiazolone, and belongs to the technical field of organic chemistry. According to the preparation method, 3-mercapto-N-n-octylpropionamide, sulfonyl chloride, and bromine are taken as the raw materials, 1, 2-dichloroethane is taken as the solvent, the raw materials are heated to carry out chlorine cyclization and bromination reactions to generate a mixture composed of 2-n-octyl-4-bromo-5-chloro-3-isothiazolone, 2-n-octyl-4,5-dichloro-3-isothiazolone, and other impurities, then the mixture is subjected to recrystallization and column chromatography to obtain pure 2-n-octyl-4-bromo-5-chloro-3-isothiazolone, and the yield is 35 to 43%. The provided preparation method overcomes the shortages of conventional synthesis technology. A novel synthesis method of 2-n-octyl-4-bromo-5-chloro-3-isothiazolone is provided.
- -
-
Paragraph 0020
(2016/10/09)
-
- STABLE COMPOSITIONS OF THIABENDAZOLE AND IODINE-CONTAINING FUNGICIDES
-
The present invention relates to stable compositions for the fungicidal equipment of thermoplastic polymers, in particular PVC, comprising thiabendazole, at least one iodine-containing fungicide and at least one epoxide and optionally further fungicidally active compounds, and also to methods for preparing these formulations and to uses thereof for the protection of thermoplastic polymers against attack and destruction by microorganisms. Moreover, the invention relates to mold-resistant PVC materials equipped with the compositions according to the invention.
- -
-
-
- Preparation of N-Substituted Isothiazolinone Derivatives
-
Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II) or N,N′-bis-substituted 3,3′-dithiodipropionamides of formula (III) with sulfuryl chloride in the absence of solvents. Also provided is a process for the preparation of a compound having the general formula (III), comprising reacting a methyl ester of formula (IV) with an amine of formula (V) in a solvent of methanol. As no addition solvent is used in the process of the invention, the cost of manufacturing and pollution to the environment can be reduced.
- -
-
Page/Page column 3
(2008/12/07)
-
- Use of riboflavin and flavin derivatives as chitinase inhibitors
-
The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.
- -
-
-
- Bromonitrothienyldioxanes
-
The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) in which R1, R2 and R3 are as defined in the description are highly suitable for use as biocides for protecting plants and industrial materials.
- -
-
-
- 3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS
-
The 3-nitroisoxazoles of the formula (I) in which R1 and R2 are each as defined in the description, some of which are known, are highly suitable for use as biocides for protecting industrial materials.
- -
-
-
- Thiazines and thiazoles as agents for protecting materials
-
The novel and known thiazines and thiazoles of the formula (I) in which R1, R2 and n are as defined in the description, are highly suitable for use as biocides for protecting industrial materials.
- -
-
-
- O-aryl dithiazole dioxides
-
The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.
- -
-
-
- Agents for preserving technical materials against insects
-
The use of the compounds of the formula (I) as agents for preserving technical materials against insects.
- -
-
-
- Dithiazoldioxides and the use thereof as microbicides
-
The invention relates to novel dithiazole dioxides, to processes for their preparation and to their use in crop protection and in the protection of materials.
- -
-
-
- Arylthio-dithiazindioxides and their use as pesticides
-
PCT No. PCT/EP97/07242 Sec. 371 Date Jun. 23, 1999 Sec. 102(e) Date Jun. 23, 1999 PCT Filed Dec. 22, 1997 PCT Pub. No. WO98/29400 PCT Pub. Date Jul. 9, 1998The invention relates to novel S-aryl-dithiazine dioxides, to processes for their preparation and to the use in crop protection and in the protection of materials.
- -
-
-
- N-sulfonyliminodithio compounds useful for in plant and material protection
-
N-sulfonyliminodithio compounds have the formula (I), in which R1 and R2 stand for optionally substituted alkyl, alkenyl or alkinyl, and Ar stands for optionally substituted aryl; also disclosed are processes for preparing these compounds and their use for plant and material protection. STR1
- -
-
-
- 1,3,2-benzodithiazol-1-oxides as microbiocides
-
A description is given of novel and know 1,3,2-benzodithiazole 1-oxides of the formula (I) STR1 and of their preparation and use for protecting industrial materials against infestation by microorganisms.
- -
-
-
- Mould-resistant emulsion paints
-
The application relates to emulsion paints which are protected against fungal infestation by the use of N-alkyl-benzothiophene-2-carboxamide S,S-dioxides.
- -
-
-
- Thiazolylpyrazolinones and their use for protecting technical materials
-
The present invention relates to novel thiazolylpyrazolinones, a process for their preparation and their use for the protection of technical materials.
- -
-
-
- Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock
-
This application relates to new thiocarbamoyl compounds of the formula (I) STR1 in which R1, R2, R3 and R4 have the meanings given in the description.
- -
-
-
- Termite-controlling agent composition
-
Combating termites with a composition comprising (a) at least one compound of the formula STR1 wherein, R denotes a hydrogen atom, acyl, alkyl or optionally substituted heteroarylalkyl, A denotes a hydrogen atom, alkyl or a bivalent group which binds to B, D denotes alkyl, --S--R1, STR2 or bivalent group or atom which binds to A. wherein R1 or R2 each independently denotes a hydrogen atom, acyl, alkyl or optionally substituted heteroarylalkyl. Y denotes =N-- or STR3 wherein T1 denotes a hydrogen atom or optionally substituted alkyl, and X denotes an electron attracting group, and (b) a pyrethoid compound.
- -
-
-
- Agents for preserving technical materials against insects
-
Agents for preserving technical materials against insects, characterized in that they contain at least one compound of the formula (I) wherein Z represents 2-chloro-5-pyridiyl or 2-chloro-5-thiazolyl, and, R1 and R2 each independently represents hydrogen or C 1 4 alkyl.
- -
-
-
- Preparation of halo substituted isothiazolones
-
This invention relates to an improved preparation of halo substituted isothiazolones by a single-step synthesis. The products are useful as biocides.
- -
-
-
- Protracted release microbiocidal article for aqueous systems
-
There is disclosed as an article a water-permeable membrane containing sealed therein a solid particulate microbiocidal composition which is useful in aqueous systems, wherein the composition is produced from a microbiocidal compound having relatively low water solubility or a combination thereof with other microbiocidal compounds having relatively high water solubility to give a combination generally characterized by low water solubility in admixture with an inert, finely-divided water-insoluble solid carrier material. Especially useful are microbiocidal 3-isothiazolones and 2-substituted-1,2-benzisothiazolones having relatively low water solubility, and metal salt stabilized derivatives thereof, admixed with silicaceous diatomaceous earth. These articles afford protracted controlled release of active ingredient and also afford a safer form of the active ingredient heretofore known to be relatively irritating to the skin of man when at high concentration in aqueous solution.
- -
-
-
