- A pramoxine hydrochloride preparing method
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The invention belongs to the technical field of medicine synthesis, and particularly relates to a pramoxine hydrochloride preparing method. The method includes reacting p-bromophenol and 1-bromobutaneunder catalytic functions of an alkali to prepare an intermediate that is 1-bromo-4-tert-butoxybenzene; synthesizing pramoxine having a base group from the 1-bromo-4-tert-butoxybenzene and 3-morpholinopropanol with the existence of a strong alkali; and subjecting the pramoxine having the base group to salification to obtain the pramoxine hydrochloride. The yield of the pramoxine hydrochloride prepared by the method is higher than 80%, and liquid-phase purity of the prepared pramoxine hydrochloride is higher than 99.8%. The method is used for preparing the pramoxine hydrochloride, and is simple to operate and high in yield, raw materials are easily available, product purity is high, the cost is low, and pollution is low.
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Paragraph 0019; 0021
(2018/04/21)
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