- Base-promoted reactions in ionic liquid solvents. The Knoevenagel and Robinson annulation reactions
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When used in place of classical organic solvents, ionic liquids offer a new and environmentally benign approach toward solvation in modern synthetic chemistry. Two classical named reactions, the Knoevenagel condensation and Robinson annulation, have been
- Morrison, Doug W,Forbes, David C,Davis Jr., James H
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- One-pot insertion of chalcones into the benzoylacetone backbone
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Interaction of 1-phenylbutane-1,3-dione and chalcones in the presence of a base gives, in one step, good to high yields cyclic and unusual acyclic insertion products in ratios which depend on substrate, catalyst, and reaction conditions. All the synthesiz
- Naghiyev, Farid N.,Gurbanov, Atash V.,Maharramov, Abel M.,Mamedov, Ibrahim G.,Allahverdiyev, Mirze A.,Mahmudov, Kamran T.
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- Nylon monomer and preparation method thereof
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The invention provides four nylon monomers and a preparation method thereof, wherein a nylon monomer is formed at 3 positions and 5 positions of a lactam or pimelic acid, and a preparation method of the nylon monomer is used for chalcone. The ethyl acetoa
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Paragraph 0028; 0031-0032
(2021/10/16)
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- Metal-Free I2-Catalyzed Highly Selective Dehydrogenative Coupling of Alcohols and Cyclohexenones
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The I2 catalyzed highly selective oxidative condensation of cyclohexenones and alcohols for the synthesis of aryl alkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.
- Liang, Yu-Feng,Yuan, Yizhi,Shen, Tao,Song, Song,Jiao, Ning
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supporting information
p. 233 - 240
(2018/02/19)
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- Conversion of Simple Cyclohexanones into Catechols
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A novel I2-catalyzed direct conversion of cyclohexanones to substituted catechols under mild and simple conditions has been described. This novel transformation is remarkable with the multiple oxygenation and dehydrogenative aromatization processes enabled just by using DMSO as the solvent, oxidant, and oxygen source. This metal-free and simple system demonstrates a versatile protocol for the synthesis of highly valuable substituted catechols and therefore streamlines the synthesis and modification of biologically important molecules for drug discovery.
- Liang, Yu-Feng,Li, Xinyao,Wang, Xiaoyang,Zou, Miancheng,Tang, Conghui,Liang, Yujie,Song, Song,Jiao, Ning
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supporting information
p. 12271 - 12277
(2016/09/28)
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- A highly efficient metal-free approach to: Meta - And multiple-substituted phenols via a simple oxidation of cyclohexenones
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A novel and efficient metal-free approach to substituted phenols has been disclosed from simple and readily available cyclohexenones and cyclohexenone equivalents. Dimethyl sulfoxide (DMSO), a simple and common organic reagent, was employed as a mild oxidant in this I2-catalysis, which significantly tolerates various substituents including some easily oxidizable or reducible functionalities. The challenging meta- and multiple-substituted phenols could be well prepared by this method. The metal-free and mild oxidation make this protocol very simple, practical, and easy to handle.
- Liang, Yu-Feng,Song, Song,Ai, Lingsheng,Li, Xinwei,Jiao, Ning
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supporting information
p. 6462 - 6467
(2018/06/08)
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- Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives
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Novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives were synthesized and characterized by using spectral techniques like IR, 1H NMR, 13C NMR, COSY, DEPT, and GC-MS. All these compounds were screened for anti-fungal, anti-bacterial and anti-oxidant activity. Cyclohexenone derivatives, in general, showed better anti-fungal and anti-bacterial activity than parent chalcones. Whereas, all the Indazole derivatives showed very good anti-oxidant activity and some were also found to be active as anti-bacterial agent. Among the screened compounds, 15 was found to be most active as anti-fungal agent (against Rhizoctonia solani, LC 50 = 2.36 μg mL-1), 15b was found to be most active anti-bacterial agent (against Klebsiella pneumonia, MIC = 24.68 μg mL -1) and 14b emerged as most active anti-oxidant (IC50 = 19.81 μg mL-1).
- Shakil,Singh, Manish K.,Sathiyendiran,Kumar,Padaria, Jasdeep C.
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p. 120 - 131
(2013/03/14)
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- 1H and 13C NMR spectral study of some 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones - A study of four-bond 1H-1H couplings
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Nine 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones 2a-2i have been synthesized. For all these compounds, 1H and 13C NMR spectra have been recorded. For two compounds, 2D spectra have been recorded. The spectral data suggest that thes
- Yuvaraj,Pandiarajan
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experimental part
p. 253 - 257
(2011/10/19)
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- Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents
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An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 against M.luteus, K.pneumonia, 29, 30 against P.vulgaris exhibited excellent antibacterial activity at a minimum inhibitory concentration (MIC) value of 6.25 μg/mL. Compound 23 against M.gypseum, 25, 29 against Candida 6 and 29, 30 against C.albicans revealed excellent antifungal activity at a MIC value of 6.25 μg/mL.
- Kanagarajan,Thanusu,Gopalakrishnan
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scheme or table
p. 280 - 287
(2011/10/18)
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- Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates as a new class of antibacterial and antifungal agents
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A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6- carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex- 3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.
- Thanusu,Kanagarajan,Gopalakrishnan
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scheme or table
p. 575 - 583
(2012/01/19)
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- Efficient microwave activation of hydrotalcite clays in Michael addition under solvent-free conditions
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Microwave irradiation has been successfully utilized for the first time for the activation of unmodified hydrotalcites (HTs, a basic anionic clay), in the Michael addition reaction between enones and active methylenic compounds under solventless condition
- Vijaikumar, Sakthivel,Pitchumani, Kasi
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experimental part
p. 469 - 474
(2010/11/04)
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- A simple and practical method for the synthesis of 2-amino-5,6-dihydro-5,7- diarylquinazolin-4-ols
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(Chemical Equation Presented) We report an efficient and new method of synthesis of 2-amino-5,6-dihydro-5,7-diarylquinazolin-4-ols by the reaction of substituted cyclohexenones with guanidine hydrochloride in presence of NaOEt. The reactions are with 50-72% yield. All the synthesized compounds are characterized using IR, NMR and CHN analysis.
- Senguttuvan,Nagarajan, Samuthira
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experimental part
p. 1346 - 1348
(2010/03/26)
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- Microwave assisted rapid and efficient. synthesis of new 3-ethoxy-4,6-diaryl-4,5- Dihydro-2,1-benzisoxazoles
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A simple, extremely fast and efficient synthesis of new 3- ethoxy-4,6-diaryl-4,5-dihydro2,l-benzisoxazoles has been achieved under microwave irradiation.
- Rajanarenda,Rao,Raju
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experimental part
p. 749 - 753
(2009/12/28)
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- Synthesis and characterization of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols - A new series of fused indazole derivatives
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A novel class of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols is synthesized and characterized by melting point, elemental analysis, MS, FT-IR, 1H and 13C NMR, D2O exchanged 1H NMR, and two-dimensional HSQC spectra.
- Gopalakrishnan,Thanusu,Kanagarajan
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body text
p. 950 - 955
(2009/04/16)
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- A rapid one-pot synthesis of 2,4,6-triaryl-3-aroyl-4-hydroxy-1,1-cyclohexanedicarbonitriles and 2-aminoisophthalonitriles under microwave activation
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Ylidenemalononitriles 1 react with a variety of 1,3-diaryl-2-propen-1-ones 2 at ambient temperature and pressure under microwave activation to yield functionalised cyclohexanedicarbonitriles 3 and 2-aminoisophthalonitriles 4 in good yields.
- Laskar, Dhrubojyoti D.,Prajapati, Dipak,Sandhu, Jagir S.
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p. 135 - 139
(2007/10/03)
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- Michael addition catalyzed by potassium hydroxide under ultrasound
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Michael addition of chalcone with active methylene compound such as diethyl malonate, nitromethane and ethyl acetoacetate catalyzed by potassium hydroxide in anhydrous ethanol results Michael adducts in 75-98% yield under ultrasound irradiation in 25-90 m
- Li, Ji-Tai,Cui, Yong,Chen, Guo-Feng,Cheng, Zhao-Li,Li, Tong-Shuang
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p. 353 - 359
(2007/10/03)
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- Cyclohexenone carboxylates. A versatile source for fused isoxazoles and pyrazoles
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The 6-carbethoxy-3,5-diarylcyclohex-2-enone (1) was subjected to condensation and 1,3-dipolar cycloaddition reactions to get fused isoxazole and pyrazole derivatives.
- Padmavathi,Sharmila,Balaiah,Somasekhar Reddy,Bhaskar Reddy
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p. 2119 - 2126
(2007/10/03)
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- Synthesis of Ethyl 5-Aryl-2-oxo-7-phenyl-1,2,3,4,4a,5-hexahydroquinoline-4a-carboxylates
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The addition of ethyl 6-aryl-4-phenyl-2-oxo-3-cyclohexene-1-carboxylates 1a-e to acrylonitrile in the presence of aqueous sodium hydroxide is studied.The products 2a-e are transformed to the corresponding 2-oxo-1,2,3,4,4a,5-hexahydroquinolines 3 by heatin
- Popandova-Yambolieva, K.
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- Ba(OH)2 AS CATALYST IN ORGANIC REACTIONS-PART XVI-CONTRIBUTION TO THE STUDY OF THE MICHAEL ADDITION MECHANISM TO CHALCONE IN INTERFACIAL SOLID-LIQUID CONDITIONS
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The Michael addition of several active methylene compounds to chalcone, catalyzed in interfacial solid-liquid conditions is described.The mechanism of the process is analyzed using the Michael addition of diethyl malonate to chalcone as the reaction test.
- Iglesias, M.,Marinas, J.M.,Sinisterra, J.V.
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p. 2335 - 2342
(2007/10/02)
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- Synthesis and Structure of Diastereomeric 2,4,6,8-Tetraaryl-3-azabicyclononanes and their Conformation in the Crystal and in Solution. Stereochemistry of the Mannich Reaction of cis-3,5-Diphenylcyclohexanone and -4-heteracyclohexanones
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In the Mannich reaction with ammonium acetate and benzaldehyde, cis-3,5-diphenylcyclohexanone (3a) afforded a mixture of the diastereomeric tetraphenyl-3-azabicyclononanones 4a(A) = 14a and 4a(B) = 2a.In contrast, the use of 4-chlorobenzaldehyde in
- Quast, Helmut,Mueller, Bodo,Peters, Eva-Maria,Peters, Karl,Schnering, Hans Georg von
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p. 424 - 437
(2007/10/02)
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