Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor
The standard glycine site antagonist of the N-methyl-D-aspartate (NMDA) receptor, 3-phenyl-4-hydroxyquinolin-2(1H)-one (21), was used as a template for bioisostere benzene/thiophene exchange. Phenylacetylation of aminothiophene carboxylic acid methyl este
Buchstaller, Hans-Peter,Siebert, Carsten D.,Steinmetz, Ralf,Frank, Ina,Berger, Michael L.,Gottschlich, Rudolf,Leibrock, Joachim,Krug, Michael,Steinhilber, Dieter,Noe, Christian R.
p. 864 - 871
(2007/10/03)
Acylamino derivatives
Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 5-membered ring containing a single heteroatom, which may be oxygen, or sulphur, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
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(2008/06/13)
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