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61478-26-0

Articles about 61478-26-0Total 5 be found

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OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
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(2015/02/02)

Substituted Imidazopyridines as HDM2 Inhibitors
The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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(2014/07/08)

A practical synthesis of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane
The rigid piperazine homologue 2,5-diazabicyclo[2.2.1]heptane (DBH) finds extensive application in medicinal chemistry and pharmaceutical research, but access to this scaffold is non-trivial. This letter details a concise synthetic sequence that gives ready access to DBH on gram scale. The route features a Staudinger reduction of an azide to facilitate a transannular cyclisation.
Beinat, Corinne,Banister, Samuel D.,McErlean, Christopher S.P.,Kassiou, Michael
p. 5345 - 5347
(2013/09/12)

Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives
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Jordis,Sauter,Siddiqi,Kuenburg,Bhattacharya
p. 925 - 930
(2007/10/02)

Synthesis of (1S,4S)-2-Thia-5-azabicycloheptane
Starting from trans-4-hydroxy-L-proline, (1S,4S)-2-thia-5-azabicycloheptane (1) has been synthesised via the key intermediate N-(t-butoxycarbonyl)-trans-4-hydroxy-L-prolinol ditosylate (7).
Jordis, Ulrich,Sauter, Fritz,Siddiqi, Suhaib M.
p. 294 - 296
(2007/10/02)

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Chemical Properties

Melting Point: 81-86 °C(lit.)
Boiling Point: 340.296 °C at 760 mmHg
Flash Point:159.605 °C
Density: 1.19 g/cm³
Solubility:Chloroform (Slightly), Methanol (Slightly)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index: 1.511
PKA: 14.57±0.40(Predicted)
Sensitive: Air Sensitive
PSA: 70.00000
LogP: 0.28690

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