- Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir
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A series of 7-alkyl ether derivatives related to zanamivir were synthesized using direct alkylation of the C-7 alcohol of sialic acid. Alkyl ether moiety of less than 12 carbons in length showed low nanomolar inhibitory activity against influenza A virus sialidase. Furthermore, their moiety improved influenza A virus plaque reduction activity compared to zanamivir. However, removal of the 8,9-diol of the 7-O-alkyl derivatives resulted in loss of antiviral potency. This result suggests that 8,9-diol must play an important role in binding with both influenza A and B virus sialidases.
- Honda, Takeshi,Masuda, Takeshi,Yoshida, Shuku,Arai, Masami,Kaneko, Satoru,Yamashita, Makoto
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p. 1925 - 1928
(2007/10/03)
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- Benz (c) fluoran compounds and recording sheet containing them
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Novel benz[c]fluoran compounds such as 2-phenylamino-8-diethylamino-benz[c]fluoran, 2-(2',4',6'-trimethylphenylamino)-8-diethylamino-benz[c]fluoran and N-[8-diethylaminobenz[c]fluoran-2-yl]-N-[6-diethylaminofluoran-2-yl]amine, which are useful as a coloring material for record material systems such as pressure-sensitive copying paper or heat-sensitive copying paper, wherein colored images formed by an electron-donoracceptor color-forming reaction between coloring material and acidic material.
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- Chromogenic compounds and method for preparation thereof
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Chromogenic compounds for use in pressure sensitive recording sheets represented by the formula: SPC1 Are disclosed, wherein R1 and R2 are independently, hydrogen substituted or unsubstituted lower alkyl, aliphatic acyl, phenyl substituted aliphatic acyl, benzoyl, aralky, phenyl (the benzene nuclei of those substituents may be further substituted by chlorine, bromine, lower alkyl, lower alkoxy or nitro), allyl, allyl substituted by lower alkyl or phenyl, propargyl, or propargyl substituted by lower alkyl or a phenyl; R3 and R4 are independently lower alkyl, benzyl and phenyl (the benzene nuclei or those substiutents may be further substituted by chlorine, bromine, lower alkyl or lower alkoxy), either R1 or R2 being other than hydrogen when R3 and R4 are both ethyl groups.
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- Benzo-1,2,4-triazines
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Benzo-1,2,4-triazines-1,4-di-N-oxides substituted in the 3-position with a substituted amino group and optionally substituted in the benzo ring are antimicrobial agents. The compounds, of which 3-(N-acetoacetylamino)benzo-1,2,4-triazine-1,4-di-N-oxide is a typical embodiment, are prepared from the corresponding 2-aminobenzo-1,2,4-triazine-1,4-di-N-oxide through alkylation or acylation.
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