- A simple technique to grow polymer brushes using in situ surface ligation of an organometallic initiator
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A simple approach is described here for the in-place synthesis of polymer brushes by surface-initiated polymerization. A cyano-terminated self-assembled monolayer on a gold surface was used to anchor a highly active cationic Pd organometallic initiator by ligand exchange. We grew ultrasmooth patterned poly(4-methoxystyrene) brushes with excellent thickness control at room temperature. Copyright
- Dronavajjala, Krishna D.,Rajagopalan, Ramakrishnan,Uppili, Sundararajan,Sen, Ayusman,Allara, David L.,Foley, Henry C.
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Read Online
- DIENE GEMINI POLYMERIZABLE SURFACTANTS WITH MIXED CIS AND TRANS ISOMERS THAT FORM BICONTINUOUS CUBIC PHASES
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A polymerizable Gemini surfactant based on tail groups with mixed isomer dienes. The Gemini surfactants may be produced having imidazolium head groups and diene tail groups with a near-equal abundance of the ?" and "Z" isomers. These compounds are lyotropic liquid crystals that can form bicontinuous cubic phases by self-assembly.
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Paragraph 0071
(2020/02/06)
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- New fluorinated agonists for targeting the sphingosin-1-phosphate receptor 1 (S1P1)
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The sphingosine-1-phosphate receptor type 1 (S1P1) is involved in fundamental biological processes such as regulation of immune cell trafficking, vascular barrier function and angiogenesis. This Letter presents multistep syntheses of various fluorine substituted 12-aryl analogues of the drug fingolimod (FTY720) and a seven-steps route to 2-amino-17,17-difluoro-2-(hydroxymethyl)heptadecan-1-ol. In vitro and in vivo tests proved all these compounds as potent S1P1 receptor agonists.
- Shaikh, Rizwan S.,Keul, Petra,Sch?fers, Michael,Levkau, Bodo,Haufe, Günter
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supporting information
p. 5048 - 5051
(2015/11/09)
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- Synthesis of [3]rotaxanes that utilize the catalytic activity of a macrocyclic phenanthroline-Cu complex: Remarkable effect of the length of the axle precursor
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[3]Rotaxanes, which consist of one macrocyclic phenanthroline compound and two axle components, were prepared by the oxidative dimerization of an alkyne compound with bulky tris[4'-cyclohexyl-(1,1'-biphenyl)-4-yl]methyl blocking group. The catalytic activ
- Yamashita, Yoshiaki,Mutoh, Yuichiro,Yamasaki, Ryu,Kasama, Takeshi,Saito, Shinichi
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supporting information
p. 2139 - 2145
(2015/02/19)
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- Synthesis of new ligands for targeting the S1P1 receptor
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Sphingosine-1-phosphate (S1P) influences various fundamental biological processes by interacting with a family of five G protein-coupled receptors (S1P1-5). FTY720, a sphingosine analogue, which was approved for treatment of relapsing forms of multiple sclerosis, is phosphorylated in vivo and acts as an agonist of four of the five S1P receptor subtypes. Starting from these lead structures we developed new agonists for the S1P1 receptor. The biological activity was tested in vivo and promising ligands were fluorinated at different positions to identify candidates for positron emission tomography (PET) imaging after [18F]-labelling. The radioligands shall enable the imaging of S1P1 receptor expression in vivo and thus may serve as novel imaging markers of S1P-related diseases.
- Schilson, Stefanie S.,Keul, Petra,Shaikh, Rizwan S.,Sch?fers, Michael,Levkau, Bodo,Haufe, Günter
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p. 1011 - 1026
(2015/03/04)
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- NEW LIGANDS FOR TARGETING OF S1P RECEPTORS FOR IN VIVO IMAGING AND TREATMENT OF DISEASES
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The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.
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Paragraph 0262; 0263; 0264; 0265; 0266
(2014/06/25)
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- NEW LIGANDS FOR TARGETING OF S1P RECEPTORS FOR IN VIVO IMAGING AND TREATMENT OF DISEASES
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The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.
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Page/Page column 32
(2013/03/26)
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- General synthesis and aggregation behaviour of a series of single-chain 1,ω-Bis(phosphocholines)
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The synthesis and physicochemical characterisation of a series of polymethylene-1,ω-bis(phosphocholines) with even-numbered chain lengths between 22 and 32 carbon atoms is described. Two new synthetic strategies for the preparation of long-chain 1,ω-diols as hydrocarbon building blocks are presented. The temperature-dependent self-assembly of the single-chain bolaamphiphiles was investigated by cryo transmission electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR).
- Drescher, Simon,Meister, Annette,Blume, Alfred,Karlsson, Goeran,Almgren, Mats,Dobner, Bodo
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p. 5300 - 5307
(2008/02/11)
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- The introduction of π-π stacking moieties for fabricating stable micellar structure: Formation and dynamics of disklike micelles
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(Figure Presented) Enhancing the intermolecular interactions between micelles by introducing a strong π-π stacking moiety and flexible spacers of appropriate length results in the formation of disklike micelles that can maintain their monomolecule-layered
- Song, Bo,Wang, Zhiqiang,Chen, Senlin,Zhang, Xi,Fu, Yu,Smet, Mario,Dehaen, Wim
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p. 4731 - 4735
(2007/10/03)
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- PROCESS FOR PRODUCING CYCLOHEXENONE LONG-CHAIN ALCOHOLS
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A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R1, R2, and R3 individually represents hydrogen o
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- Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship
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Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.
- Girlanda-Junges, Celine,Keyling-Bilger, Florence,Schmitt, Gaby,Luu, Bang
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p. 7735 - 7748
(2007/10/03)
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