Oxidative amidation of aldehydes and alcohols with primary amines catalyzed by KI-TBHP
Oxidative amidation of aldehydes and alcohols with amines to afford the corresponding amides in excellent yields and ee values over 98% is achieved by using a catalytic amount of KI in combination with TBHP as the external oxidant. This method avoids the use of expensive and/or air-sensitive reagents. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.