Heterocycle type derivative and preparing method and pharmaceutical application thereof
The invention relates to a novel heterocycle type derivative, a preparing method thereof, a medicine composition containing the derivative and application of the heterocycle type derivative as therapeutic agent, particularly an FGFR4 inhibitor. The preferable compound has a good inhibiting effect on FGFR4.
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Paragraph 0243; 0246; 0251-0253
(2018/07/30)
Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation
Disclosed herein are angiogenesis inhibitors represented by formula (I) or formula (II): The variables for formulas (I) and (II) are defined herein.
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Page/Page column 21-22
(2010/11/28)
Synthesis of meta-substituted aniline derivatives by nucleophilic substitution
Substitution by amines of fluorobenzenes containing a meta- substituted electron withdrawing group (EWG), in DMSO at 100 °C over 60 h gave meta-substituted aniline derivatives in isolated yields of up to 98%. The scope of the reaction is explored in terms of reaction conditions and substrates. It is postulated that facile meta-substitutions are facilitated through field stabilisation of the intermediate anion by EWG substituents.
Belfield, Andrew J.,Brown, George R.,Foubister, Alan J.,Ratcliffe, Paul D.
p. 13285 - 13300
(2007/10/03)
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