- New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases
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The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and N6-position, respectively, is reported. The compounds were tested with radioligand binding studies showing, in some cases, a low
- Lambertucci, Catia,Marucci, Gabriella,Dal Ben, Diego,Buccioni, Michela,Spinaci, Andrea,Kachler, Sonja,Klotz, Karl-Norbert,Volpini, Rosaria
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p. 199 - 213
(2018/04/05)
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- INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE
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The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
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Page/Page column 136-137
(2012/04/04)
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- New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A1 adenosine receptor antagonists
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A new series of 9-methyladenines, bearing different bulky groups at the 8-position, were prepared and their affinity for the four human adenosine receptor subtypes were evaluated. All the synthesized compounds showed affinities at the A1, Asub
- Lambertucci, Catia,Buccioni, Michela,Cacciari, Barbara,Dal Ben, Diego,Federico, Stephanie,Klotz, Karl-Norbert,Marucci, Gabriella,Volpini, Rosaria,Spalluto, Giampiero,Cristalli, Gloria
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scheme or table
p. 1379 - 1393
(2012/04/17)
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- Novel 8-arylated purines as inhibitors of glycogen synthase kinase
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A series of 8-arylated purine derivatives bearing either an aniline or an alkyl amide at position 6 were found to inhibit glycogen synthase kinase-3,with good selectivity over ten kinases. Molecular modeling studies indicated that the most active compounds (8a and 8e),adopt a planar conformation,close to the shape of AMPPNP in the crystal structure of GSK-3. These compounds are stabilized by hydrophobic contacts between the 8-aromatic group and the protein adenine pocket and by electrostatic contacts.
- Ibrahim, Nada,Mouawad, Liliane,Legraverend, Michel
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scheme or table
p. 3389 - 3393
(2010/08/06)
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- AMINOPYRIMIDINAMIDES AS PESTICIDES
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The present application relates to novel aminopyrimidinamides, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
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Page/Page column 15
(2010/12/29)
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- Heterocyclic Compounds Useful as RAF Kinase Inhibitors
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The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
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Page/Page column 21
(2009/01/24)
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- Compounds containing a N-heteroaryl moiety linked to fused ring moieties for the inhibition of NAD(P)H oxidases and platelet activation
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The invention relates to compounds containing a N-heteroaryl moiety, which is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to a fused ring moiety, in particular to the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl radical. The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidases-related diseases and disorders and inhibition of platelet activation.
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Page/Page column 91
(2008/06/13)
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