Stereospecific synthesis of cyclic hydrazoacetic acids and meso- diaminodicarboxylic acids
The hetero Diels-Alder adducts 6a - d derived from azodibenzoyl and cyclic dienes were oxidized by ruthenium tetroxide and transformed into meso- diaminodicarboxylic acids 12a - d via the new cyclic hydrazoacetic acids 9a - d.
Synthesis of (2S,5S)-5-fluoromethylornithine; a potent inhibitor of ornithine aminotransferase
Only one of the four enantiomers of 5-fluoromethylornithine 1 was an irreversible inhibitor of ornithine aminotransferase. The active enantiomer la was synthesized from diaminoadipic acid 2 with a chemical diastereomeric separation and an enantiomeric res