- INHIBITORS OF APOL1 AND METHODS OF USING SAME
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The disclosure provides at least one entity chosen from compounds of Formula (I) pharmaceutically acceptable salts thereof, solvates of any of the foregoing, and deuterated derivatives of any of the foregoing, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.
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Paragraph 00147; 00161
(2021/08/06)
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- INHIBITORS OF APOL1 AND METHODS OF USING SAME
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The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
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Paragraph 00368
(2020/07/14)
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- Aryl trifluoroborates in Suzuki-Miyaura coupling: The roles of endogenous aryl boronic acid and fluoride
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Undercover agents: The biaryl coupling of an aryltrifluoroborate with an aryl bromide involves in situ hydrolysis of the boron reagent. The hydrolysis products are key components in ensuring that the reaction proceeds with high efficiency and avoids the e
- Butters, Mike,Harvey, Jeremy N.,Jover, Jesus,Lennox, AlastairJ J.,Lloyd-Jones, Guy C.,Murray, Paul M.
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supporting information; experimental part
p. 5156 - 5160
(2010/11/04)
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- Convenient methods for the synthesis of d4, d2 and d6 isotopomers of 4-(4-fluorobenzyl)piperidine
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Pure 4-(4-fluoro-[2,3,5,6-2H4]benzyl)piperidine was prepared via the Grignard reaction of 4-fluoro-[2,3,5,6-2H 4]bromobenzene and pyridine-4-aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4-(4-fluorobenzyl)piperidine and its d4 derivative has also been described. Copyright
- Proszenyak, Agnes,Agai, Bela,Tarkanyi, Gabor,Vida, Laszlo,Faigl, Ferenc
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p. 421 - 427
(2007/10/03)
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