- ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
-
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
- -
-
Page/Page column 73-74
(2011/06/19)
-
- 17O, 13C and 1H NMR spectra of 1,2-dialkoxyethenes
-
The 17O, 13C and 1H NMR spectra of a number of 1,2-dialkoxyethenes R1OCH=CHOR2 were recorded. The O atoms, in particular those of the E forms, are strongly shielded relative to the 17O nuclei of the corresponding alkyl vinyl ethers ROCH=CH2. Moreover, in compounds of the type ROCH=CHOMe, the difference δ(17O)Z - δ(17O)E of the MeO group decreases and that of the RO group increases with increasing bulkiness of R. These trends probably arise from changes, with the size of the alkyl group R, in the stereochemistry of the RO group of the E-isomer about the O - C(sp2) bond, whereas the stereochemistry of the Z-form seems to be independent of the size of R. Additional information on the stereochemistry of the title compounds is provided by their 13C and 1H NMR spectra.
- Taskinen, Esko
-
p. 573 - 578
(2007/10/03)
-
- Umsatz und kinetische Modellierung der Bildung von Formaldehyd, Ethylenglycol und Ameisensaeure bei der oxidativen Alkohol-Thermolyse
-
In this paper the investigation about oxy-thermolysis of simple organic compounds is extended to the formation of aldehyds, ethylene glycol, formic acid and others received from methanol and ethanol in the occurence of oxygen in the temperature range 900 K T 1100 K.Probable intermediate radicalic species are CH3O and CH2OH, kinetically treated as one kind of molecules.An improved system of reaction rate equations is solved.The calculated concentrations depending on time reach a maximum near 0.3 s and are compared with measured chemical concentrations.Finally it is given a sensitivity analysis of the reaction rate system.
- Spangenberg, H.-J.,Lachmann, J.,Boerger, I.,Dessau, L.,Fiebig, W.,Levitzky, A. A.
-
-
- CHEMISTRY OF ENOL ETHERS. LXXXVIII. CONDENSATION OF THE TETRAETHYLACETAL OF MALONALDEHYDE WITH β-SUBSTITUTED ENOL ALKYL ETHERS
-
The action of β-substituted enol ethers on the tetraethylacetal of malonaldehyde gave the acetals of 1,5- and 1,7-dialdehydes.The nature of the substituent in the enol ether was found to affect the regioselectivity of the reaction: condensation with ethers containig an electron-wthdrawing substituent leads to 1,5-dialdehyde acetals, while condensation with ethers containig a strong electron donor substituent leads to 1,7-dialdehyde acetals.
- Makin, S. M.,Kruglikova, R. I.,Kharitonova, O. V.,Arshava, B. M.
-
p. 1846 - 1849
(2007/10/02)
-