- An electroluminescen compound and an electroluminescent device comprising the same
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The present invention relates to an organic light-emitting compound represented by chemical formula 1. An organic electroluminescent device comprising the organic light-emitting compound in the present invention has excellent power efficiency, light-emitting efficiency, and long life cycle because the present invention can be operated by a lower driving-voltage in comparison to a device comprising conventional phosphorescent host materials. [Chemical formula 1].
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Paragraph 0380-0388
(2021/07/13)
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- One-pot, three-component Fischer indolisation-N-alkylation for rapid synthesis of 1,2,3-trisubstituted indoles
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A one-pot, three-component protocol for the synthesis of 1,2,3-trisubstituted indoles has been developed, based upon a Fischer indolisation-indoleN-alkylation sequence. This procedure is very rapid (total reaction time under 30 minutes), operationally straightforward, generally high yielding and draws upon readily available building blocks (aryl hydrazines, ketones, alkyl halides) to generate densely substituted indole products. We have demonstrated the utility of this process in the synthesis of 23 indoles, benzoindoles and tetrahydrocarbazoles bearing varied and useful functionality.
- Hughes-Whiffing, Christopher A.,Perry, Alexis
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supporting information
p. 627 - 634
(2021/02/06)
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- Allylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode
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The site-selective allylative and allenylative dearomatization of indoles with alcohols was performed under carbocatalytic regime in the presence of graphene oxide (GO, 10 wt percent loading) as the promoter. Metal-free conditions, absence of stoichiometric additive, environmentally friendly conditions (H2O/CH3CN, 55 °C, 6 h), broad substrate scope (33 examples, yield up to 92 percent) and excellent site- and stereoselectivity characterize the present methodology. Moreover, a covalent activation model exerted by GO functionalities was corroborated by spectroscopic, experimental and computational evidences. Recovering and regeneration of the GO catalyst through simple acidic treatment was also documented.
- Lombardi, Lorenzo,Bellini, Daniele,Bottoni, Andrea,Calvaresi, Matteo,Monari, Magda,Kovtun, Alessandro,Palermo, Vincenzo,Melucci, Manuela,Bandini, Marco
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p. 10427 - 10432
(2020/07/24)
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- Heterocyclic com pounds and organic light-emitting diode including the same
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The present invention relates to a novel heterocyclic compound and an organic electroluminescent device comprising the same. The heterocyclic compound is represented by the following Chemical Formula 1, and the organic electroluminescent device including the heterocyclic compound has excellent driving voltage, luminous efficiency, and lifespan properties. Chemical Formula 1. (by machine translation)
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- An electroluminescen compound and an electroluminescent device comprising the same
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The present invention relates to an organic light-emitting compound represented by chemical formula 1. An organic electroluminescent device comprising the organic light-emitting compound in the present invention has excellent power efficiency, light-emitting efficiency, and long life cycle because the present invention can be operated by a lower driving-voltage in comparison with a device comprising conventional phosphorescent host materials.
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- Heterocyclic com pounds and organic light-emitting diode including the same
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The present invention relates to a novel heterocyclic compound and an organic electroluminescent device comprising the same. The heterocyclic compound is represented by the following Chemical Formula 1, and the organic electroluminescent device including the heterocyclic compound has excellent driving voltage, luminous efficiency, and lifespan properties. Chemical Formula 1. (by machine translation)
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Paragraph 0444; 0463-0468; 0624-0630
(2021/01/29)
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- An electroluminescent compound and an electroluminescent device comprising the same
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The present invention relates to an organic light-emitting compound represented by [Chemical formula 1]. An organic electroluminescent device comprising the organic light-emitting compound in the present invention has excellent power efficiency, light-emitting efficiency, and long life cycle because the present invention can be operated by a lower driving-voltage in comparison with a device comprising conventional phosphorescent host materials. [Chemical formula 1].
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Paragraph 0306; 0327-0334
(2020/09/26)
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- Fe-Catalyzed Sequential C(sp3)-H/N-H Annulation of 2-Methylindoles with Ethyl Trifluoropyruvate at Room Temperature: Construction of Pyrrolo[1,2-α]indoles
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An efficient and benign iron-catalyzed room-temperature method was developed for direct sequential C(sp3)-H/N-H annulation to construct pyrroloindole scaffolds. This strategy features cheap and readily available raw materials and mild room-temperature reaction conditions and provides a green and practical method for the one-pot rapid synthesis of a wide range of diversely functionalized pyrrolo[1,2-α]indoles.
- Wang, Le,Wang, Le,Zhou, Jia,Chen, Han-Qia,Li, Dong-Li,Lin, Jun-Bing,Lin, Jun-Bing,Li, Ke,Ding, Tong-Mei,Zhang, Shu-Yu,Zhang, Shu-Yu
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supporting information
p. 4716 - 4720
(2020/06/29)
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- B(C6F5)3-Catalyzed Direct C3 Alkylation of Indoles and Oxindoles
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The direct C3 alkylation of indoles and oxindoles is a challenging transformation, and only a few direct methods exist. Utilizing the underexplored ability of triaryl boranes to mediate the heterolytic cleavage of α-nitrogen C-H bonds in amines, we have developed a catalytic approach for the direct C3 alkylation of a wide range of indoles and oxindoles using amine-based alkylating agents. We also employed this borane-catalyzed strategy in an alkylation-ring opening cascade.
- Basak, Shyam,Alvarez-Montoya, Ana,Winfrey, Laura,Melen, Rebecca L.,Morrill, Louis C.,Pulis, Alexander P.
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p. 4835 - 4840
(2020/04/22)
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- Novel organic compounds for organic light-emitting diode and organic light-emitting diode including the same
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The present invention relates to an organic electroluminescent compound represented by chemical formula A, and an organic light emitting device comprising the same. Substituents A_1 to A_4, R_1 to R_15, X_1, X_2, Y, n, q, and L are the same as defined in the detailed description of the invention.
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Paragraph 0439-0444
(2020/09/01)
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- Heterocyclic com pounds and organic light-emitting diode including the same
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PURPOSE: A heterocyclic compound and an organic electroluminescent device containing the same are provided to have superior luminescent characteristics such as stability, light emitting efficiency, and lifetime with low driving voltage. CONSTITUTION: A heterocyclic compound is denoted by chemical formula 1. An organic electroluminescent device comprises a first electrode, a second electrode, and one or more organic layers between the first and second electrodes. The organic layers contain one or more heterocyclic compounds. The organic layers are selected among a hole injection layer, a hole transport layer, a functional layer with hole injecting and transporting functions, a light emitting layer, an electron transport layer, and an electron injection layer. The light emitting layer contains one or more host compounds and dopant compounds.
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Paragraph 0479-0485
(2020/12/01)
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- Synthesis and evaluation of indole derivatives as photosynthesis and plant growth inhibitors
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Indole derivatives were synthetized based on the Fischer indole methodology using different phenyl hydrazine hydrochlorides and either cyclohexanone or 2-butanone. The pre- and post-emergent herbicidal activities were evaluated against Ipomoea grandifolia. A carbazole, 6-chloro-2,3,4,9-tetrahydro-1H-carbazole (3b), decreased the PIabs parameter by 32% and increased the cross-section related parameters, indicating the inactivation of the reaction center on photosystem II. Compound 3b acts as a post-emergent herbicide prototype since dry biomass was reduced by 50%, corroborating the fluorescence results. Comparing instead with a germination experiment, 2,3,4,9-tetrahydro-1H-carbazole (3a) was found to be the most effective agent, inhibiting seed germination by 22% and decreasing root length by 50%. The tetrahydrocarbazoles showed better results than indole derivatives potentially due to the presence of methylene groups at structures, which increase the compounds' lipophilicity and may facilitate their access to the plant. In addition, electron withdrawing groups on the aromatic ring were found to correlate with increased herbicide activity. Further optimization of this series towards the development of herbicides is ongoing.
- Mendes, Mylla Cristie Da Silva,Fazolo, Bruno Rodrigues,De Souza, Jéssica Maria,De Vasconcelos, Leonardo Gomes,De Sousa Junior, Paulo Teixeira,Dall'Oglio, Evandro Luiz,Soares, Marcos Ant?nio,Sampaio, Olívia Moreira,Vieira, Lucas Campos Curcino
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p. 1350 - 1358
(2019/06/19)
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- ORGANIC INDOLYL TRIARYLAMINE COMPOUNDS AND ELECTRONIC DEVICES COMPRISING AN ORGANIC LAYER CONTAINING SUCH COMPOUNDS
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Organic compounds of formula (I) comprising 2,3 dialkyl- or indeno- substituted, preferably, 2,3 dimethyl- or 5,6-dihydroindeno- substituted N-phenyl indole containing triaryl amines suitable for organic layers of electronic devices, such as hole transfer layers (HTL) and hole induction layers (HIL) in organic light emitting diodes (OLEDs) that show increased luminous efficiency. Such as hole throughput or hole injection layers.
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Page/Page column 20
(2018/05/27)
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- COMPOSITIONS WITH 2, 3-DISUBSTITUTED INDOLES AS CHARGE TRANSPORT MATERIALS, AND DISPLAY DEVICES FABRICATED THEREFROM
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Provided is a composition comprising a compound selected from Structure 1, as described herein:
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Paragraph 00158
(2016/08/03)
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- FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS
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The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.
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Page/Page column 47
(2015/06/08)
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- Pro-neurogenic compounds
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This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
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Page/Page column 104
(2015/09/22)
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- Catalytic methylation of C-H bonds using CO2 and H2
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Formation of C-C bonds from CO2 is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of our knowledge no catalytic methylation of C-H bonds using CO2 and H2 has been reported. Described herein is the combination of CO2 and H2 for efficient methylation of carbon nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO2/H2 system. Capturing: Carbon dioxide in the presence of H2 is shown to be an efficient methylating reagent for carbon nucleophiles such as 2-substituted indoles, pyrroles, and electron-rich arenes. Experimental data support the formal capture of formaldehyde. acac=acetylacetonate, triphos=1,1,1-tris(diphenylphosphinomethyl)ethane.
- Li, Yuehui,Yan, Tao,Junge, Kathrin,Beller, Matthias
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supporting information
p. 10476 - 10480
(2016/02/18)
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- Iron(II) bromide-catalyzed intramolecular c-h bond amination [1,2]-shift tandem reactions of aryl azides
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Iron(II) bromide catalyzes the transformation of ortho-substituted aryl azides into 2,3-disubstituted indoles through a tandem ethereal C-H bond amination [1,2]-shift reaction. The preference for the 1,2-shift component of the tandem reaction was established to be Me 1 2 Ph.
- Nguyen, Quyen,Nguyen, Tuyen,Driver, Tom G.
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supporting information
p. 620 - 623
(2013/03/13)
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- Efficient construction of fused indolines with a 2-quaternary center via an intramolecular heck reaction with a low catalyst loading
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An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused indolines with good functional group tolerance.
- Zhao, Lei,Li, Ziyuan,Chang, Lin,Xu, Jinyi,Yao, Hequan,Wu, Xiaoming
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supporting information; scheme or table
p. 2066 - 2069
(2012/06/18)
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- Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis
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Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up. Georg Thieme Verlag Stuttgart · New York.
- Zhang, Zhi-Guang,Haag, Benjamin A.,Li, Jin-Shan,Knochel, Paul
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experimental part
p. 23 - 29
(2011/02/26)
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- Development of proneurogenic, neuroprotective small molecules
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Degeneration of the hippocampus is associated with Alzheimer's disease and occurs very early in the progression of the disease. Current options for treating the cognitive symptoms associated with Alzheimer's are inadequate, giving urgency to the search for novel therapeutic strategies. Pharmacologic agents that safely enhance hippocampal neurogenesis may provide new therapeutic approaches. We discovered the first synthetic molecule, named P7C3, which protects newborn neurons from apopotic cell death, and thus promotes neurogenesis in mice and rats in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals. We describe the results of a medicinal chemistry campaign to optimize the potency, toxicity profile, and stability of P7C3. Systematic variation of nearly every position of the lead compound revealed elements conducive toward increases in activity and regions subject to modification. We have discovered compounds that are orally available, nontoxic, stable in mice, rats, and cell culture, and capable of penetrating the blood-brain barrier. The most potent compounds are active at nanomolar concentrations. Finally, we have identified derivatives that may facilitate mode-of-action studies through affinity chromatography or photo-cross-linking.
- MacMillan, Karen S.,Naidoo, Jacinth,Liang, Jue,Melito, Lisa,Williams, Noelle S.,Morlock, Lorraine,Huntington, Paula J.,Estill, Sandi Jo,Longgood, Jamie,Becker, Ginger L.,McKnight, Steven L.,Pieper, Andrew A.,De Brabander, Jef K.,Ready, Joseph M.
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supporting information; experimental part
p. 1428 - 1437
(2011/04/16)
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- Oxidative cleavage reaction of substituted indoles catalyzed by plant cell cultures
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We have developed a novel method for the oxidative cleavage of indole carbon double bonds in the presence of H2O2 using plant cell cultures as peroxidase. The oxidative method has some advantage, as features such as mild reactions, good yields, easy work-up and safety.
- Takemoto, Masumi,Iwakiri, Yasutaka,Tanaka, Kiyoshi
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p. 373 - 383
(2008/03/12)
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- Substituted phenyl indoles
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The present invention relates generally to substituted phenyl indoles and methods of using them.
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Page/Page column 17
(2008/06/13)
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