- Effect of copper(II) triflate on intramolecular Diels-Alder reaction of oxazole-olefins
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Intramolecular Diels - Alder reaction of the oxazole-olefins (8a) and (11a) was effectively promoted by addition of a catalytic amount of copper(II) triflate to afford the cyclopenta[c]pyridines (9a) and (12a), respectively.
- Ohba, Masashi,Izuta, Rie
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- PLASMA KALLIKREIN INHIBITORS AND USES THEREOF
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The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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Paragraph 0900; 0904
(2021/03/19)
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- DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS
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Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.
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Paragraph 0132; 0134; 0283
(2018/03/28)
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