- Copper nanoparticles supported on highly nitrogen-rich covalent organic polymers as heterogeneous catalysts for the ipso -hydroxylation of phenyl boronic acid to phenol
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This work describes a simple procedure for the synthesis of highly nitrogen-rich covalent organic polymers using commercially available starting materials like melamine and cyanuric chloride as a solid heterogeneous catalyst Cu/TCOP under solvothermal conditions. The structural properties of the as-synthesized solid heterogeneous catalyst were determined by X-ray diffraction (XRD), diffuse reflectance spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), 13C-CP MAS nuclear magnetic resonance spectroscopy and X-ray photoelectron spectroscopy. The catalytic activity of Cu/TCOP was investigated by focusing on the oxidation of phenylboronic acid under atmospheric conditions in an aqueous medium, achieving a very good yield up to 99%. The reaction performance was evaluated considering the effect of various parameters, such as the amount of the catalyst, reaction time, temperature, and the amount of the base and solvent. The Cu/TCOP catalyst is completely recoverable in a facile manner from the reaction mixture and the efficiency of the copper nanocatalyst can be recovered after five cycles.
- Sadhasivam, Velu,Harikrishnan, Muniyasamy,Elamathi, Ganesan,Balasaravanan, Rajendran,Murugesan, Sepperumal,Siva, Ayyanar
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supporting information
p. 6222 - 6231
(2020/05/13)
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- PAI-1 INHIBITOR
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The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: R1 represents a C6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0
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Page/Page column 273
(2011/02/17)
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- BISPHOSPHONATE COMPOUNDS
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Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.
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Page/Page column 67-68
(2011/05/05)
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- BIARYL OXYACETIC ACID COMPOUNDS
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Some embodiments of the present invention include novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. Some compounds provided include those of the general formula (I), and compounds of general formula (Ia).
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Page/Page column 47
(2011/02/24)
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- BIARYL OXYACETIC ACID COMPOUNDS
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The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds provided include those of the general formula I.
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Page/Page column 55
(2010/09/18)
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- Electronically modified polymer-supported cinchona phase-transfer catalysts for asymmetric synthesis of α-alkyl-α-amino acid derivatives
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Merrifield resin-supported hydrocinchonidinium salts containing particular functional groups that can participate in hydrogen bonding were prepared and evaluated as chiral phase-transfer catalysts using the asymmetric benzylation of glycine imine ester. These electronically modified Merrifield resin-supported phase-transfer catalysts generally provided better enantioselectivities compared to the unmodified ones. Copyright
- Shi, Qinghua,Lee, Yeon-Ju,Song, Hongrui,Cheng, Maosheng,Jew, Sang-Sup,Park, Hyeung-Geun,Jeong, Byeong-Seon
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p. 436 - 437
(2008/09/20)
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- PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE
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The invention relates toa pharmaceutical composition comprising a pyrazole-O-glucoside derivative selected from the group of compounds (1) to (29) according to claim 1 in combination with at least one second therapeutic agent which is suitable in the trea
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Page/Page column 44-45
(2008/12/07)
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- METHODS FOR PREVENTING AND TREATING METABOLIC DISORDERS AND NEW PYRAZOLE-O-GLYCOSIDE DERIVATIVES
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The invention relates to methods for preventing or treating metabolic disorders, for improving glycemic control, for preventing progression from impaired glucose tolerance, insulin resistance and/or from metabolic syndrome to type 2 diabetes mellitus, for
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Page/Page column 30; 31
(2010/11/25)
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- Asymmetric synthesis of fluorinated L-tyrosine and meta-L-tyrosines
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A convenient asymmetric synthesis of (2S)-2-amino-3-(2-fluoro-5-hydroxyphenyl) propanoic acid, (2S)-2-amino-3-(4-fluoro-3-hydroxyphenyl) propanoic acid and (2S)-2-amino-3-(2-fluoro-4-hydroxyphenyl) propanoic acid is described.Key steps include the synthes
- Monclus, Michel,Masson, Carine,Luxen, Andre
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- Unexpected Regioselectivity in the Lithiation of Fluoroanisoles
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The regioselectivity of lithiation of a series of fluoroanisoles and fluoroveratroles has been studied by determining the ratio of isomeric aldehydes produced by dimethylformamide quenching.The position of lithiation is influenced by such factors as temperature and time of the reaction.Contrary to published reports, fluorine competes significantly with the methoxy group as an ortho director in lithiation reactions.Lithiation of dimethyl-tert-butylsilyl ethers of fluorophenols proceeds exclusively ortho to fluorine.
- Furlano, David C.,Calderon, Silvia N.,Chen, George,Kirk, Kenneth L.
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p. 3145 - 3147
(2007/10/02)
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