- Are multicomponent strecker reactions of diketones with diamines under high pressure amenable to heterocyclic synthesis?
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Employing double Strecker strategy, two new heterocyclic compounds, 5,6,11,12-tetrahydro-6,11-dimethyldibenzo[b,f][1,4]diazocine-6,11-dicarbonitrile and 1,2,3,4,5,10-hexahydrophenazine-4a, 10a-dicarbonitrile, were prepared in one step albeit in low yields. The reaction has proven to be very limited, but such a sterically hindered amine as N-methylaniline underwent Strecker reaction with benzaldehyde and TMSCN to give the corresponding α-amino nitriles.
- Kumamoto, Koji,Iida, Hirokazu,Hamana, Hiroshi,Kotsuki, Hiyoshizo,Matsumoto, Kiyoshi
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p. 675 - 681
(2007/10/03)
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- Copper (I) 1,3-R2-3,4,5,6-tetrahydropyrimidin-2-ylidenes (R=mesityl, 2-propyl): Synthesis, X-ray structures, immobilization and catalytic activity
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The synthesis of novel copper (I) N-heterocyclic carbene complexes is described. Thus, reaction of CuX with 1,3-di(2-propyl)-3,4,5,6- tetrahydropyrimidin-2-ylidene yields CuX(1,3-di(2-propyl)-3,4,5,6- tetrahydropyrimidin-2-ylidene) (X=Cl, (1a), Br (1b));
- Bantu, Bhasker,Wang, Dongren,Wurst, Klaus,Buchmeiser, Michael R.
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p. 12145 - 12152
(2007/10/03)
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- Synthesis of fluoroorganic O-(Trirnethylsilyl)cyanhydrines
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Fluororganic and/or sterically hindered cyanohydrines are useful synthetic reagents, not readily available directly from e.g. aldehydes or ketones and hydrogen cyanide. By using trimethylsilyl cyanide (TMSCN), the obtained O-Silyl-cyanohydrines can be app
- Sander, Michael,Sundermeyer, Wolfgang
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p. 296 - 306
(2007/10/03)
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- On the Preparation of Acyl Cyanides from Aldehydes
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The O-silylated cyanohydrins 3 prepared from the aldehydes 1 with trimethylsilyl cyanide are oxidized photochemically or thermally with N-bromosuccinimide to afford the acyl cyanides 4a-n.Scope and limitations of the procedure are discussed.
- Haerle, Helmut,Jochims, Johannes C.
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p. 1400 - 1412
(2007/10/02)
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