- Thieno[2,3-d]pyrimidines as antagonists of the glutamate receptors
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Although the function of the kainate receptors in the brain is still not clear, they are increasingly defined as targets in the development of new classes of anti-epileptics. The thienopyrimidines described in this report were tested for their antagonisti
- Briel,Rybak,Kronbach,Unverferth
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experimental part
p. 823 - 826
(2009/04/10)
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- Efficient synthesis of14C-labeled 1H-pyrazolo[3,4-d]pyrimidine and related [4.3.0]-bicyclic pyrimidino systems
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In support of a research program aimed at discovering purine-related anticancer drug candidates, a method for the 14C-labeling of pyrazolopyrimidines utilizing the readily available labeled starting material, sodium [14C]formate, has been developed with a good overall yield. This new method was proven to be general in the preparation of other related [4.3.0]heterocycles containing N, O, and S atoms. A concise synthesis of a model compound, 8-aza-7-deaza-5′-[14C]noraristeromycin, was achieved utilizing this methodology as a key step.
- Ho, Jonathan Z.,Van Arsdale, Kyle R.,Braun, Matthew P.
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scheme or table
p. 958 - 963
(2009/03/11)
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