- INFECTION INDICATING MEDICAL DEVICES
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Provided herein is an implantable medical device capable of self-reporting microbial growth adjacent the site of the implanted device.
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Paragraph 0082
(2015/02/19)
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- Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B
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Irciniastatin A (a.k.a. psymberin) and irciniastatin B are members of the pederin natural product family, which have potent antitumor activity and structural complexity. Herein, we describe a full account of our total synthesis of (+)-irciniastatin A and (-)-irciniastatin B. Our synthesis features the highly regioselective Eu(OTf)3-catalyzed, DTBMP-assisted epoxide ring opening reaction with MeOH, which enabled a concise synthesis of the C1-C6 fragment, extensive use of AZADO (2-azaadamantane N-oxyl) and its related nitroxyl radical/oxoammonium salt-catalyzed alcohol oxidation throughout the synthesis, and a late-stage assembly of C1-C6, C8-C16, and C17-C25 fragments. In addition, for the synthesis of (-)-irciniastatin B, we achieved the C11-selective control of the oxidation stage via regioselective deprotection and AZADO-catalyzed alcohol oxidation. The synthetic irciniastatins showed high levels of cytotoxic activity against mammalian cells. Furthermore, chemical footprinting experiments using synthetic compounds revealed that the binding site of irciniastatins is the E-site of the ribosome.
- Uesugi, Shun-Ichiro,Watanabe, Tsubasa,Imaizumi, Takamichi,Ota, Yu,Yoshida, Keisuke,Ebisu, Haruna,Chinen, Takumi,Nagumo, Yoko,Shibuya, Masatoshi,Kanoh, Naoki,Usui, Takeo,Iwabuchi, Yoshiharu
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p. 12333 - 12350
(2016/01/09)
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- Copper-catalyzed methyl esterification of aromatic aldehydes and benzoic alcohols by TBHP as both oxidant and methyl source
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A copper-catalyzed synthesis of methyl esters from aromatic aldehydes in the presence of tert-butyl hydrogen peroxide (TBHP) was developed via a radical reaction mechanism. TBHP acts not only as an efficient oxidant, but also as a green methyl source in such transformation. Moreover, this method could also be efficiently extended to the methyl esterification of benzylic alcohols.
- Li, Pan,Zhao, Jingjing,Lang, Rui,Xia, Chungu,Li, Fuwei
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supporting information
p. 390 - 393
(2014/01/06)
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- TRISUBSTITUTED METHYL ALCOHOLS AND THEIR POLYMERIZABLE DERIVATIVES
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Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents.
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Paragraph 0049
(2013/07/05)
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- Indicators for detecting the presence of metabolic byproducts from microorganisms
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Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.
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Page/Page column 18; 19
(2013/05/08)
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- Synthesis of 8-desmethoxy psymberin: A putative biosynthetic intermediate towards the marine polyketide psymberin
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The synthesis of a putative biosynthetic precursor of psymberin including a formal synthesis of the natural product is described. The key step towards the densely functionalized tetrahydropyran core was an enantioselective catalytic Mukaiyama aldol reacti
- Bielitza, Max,Pietruszka, J?rg
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supporting information
p. 8300 - 8308
(2013/07/25)
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- INDICATORS FOR DETECTING THE PRESENCE OF METABOLIC BYPRODUCTS FROM MICROORGANISMS
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Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.
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- Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system
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A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct
- Wehlan, Hermut,Jezek, Eva,Lebrasseur, Nathalie,Pave, Gregoire,Roulland, Emmanuel,White, Andrew J. P.,Burrows, Jeremy N.,Barrett, Anthony G. M.
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p. 8151 - 8158
(2007/10/03)
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- Synthesis of 3-arylisocoumarins, including thunberginols A and B, unsymmetrical 3,4-disubstituted isocoumarins, and 3-ylidenephthalides via iodolactonization of methyl 2-ynylbenzoates or the corresponding carboxylic acids
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3-Aryl-4-iodoisocoumarins, which were readily and efficiently prepared by regioselective iodolactonization of methyl 2-ynylbenzoates or the corresponding carboxylic acids, were used as precursors either to 3-arylisocoumarins, including naturally-occurring
- Rossi, Renzo,Carpita, Adriano,Bellina, Fabio,Stabile, Paolo,Mannina, Luisa
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p. 2067 - 2081
(2007/10/03)
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