- α-Chlorination of Carboxylic Acids Using Trichloroisocyanuric Acid
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Carboxylic acids are chlorinated in the a position by heating with trichloroisocyanuric acid after formation of a small amount of the acid chloride using phosphorus trichloride.
- Hiegel, Gene A.,Faher, Diane Dutton,Lewis, Justin C.,Tran, Tan Duc,Hobson, Gregory G.,Farokhi, Farhad
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- Decyclization of chlorocyclohexanone hydroperoxides under the action of ferrous salts
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The decomposition of 2-chloro-, 2,2-dichloro-, and 2,6-dichloro-substituted cyclohexanone hydroperoxides on treatment with ferrous chloride and sulfate to give chloro-substituted aliphatic acids was investigated. A method for the synthesis of 2,6,6-trichlorohexanoic and 2,6,7,11-tetrachlorododecane-1,12-dioic acids was elaborated.
- Starostin,Gushchin,Ignatenko,Aleksandrov,Nikishin
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p. 133 - 136
(2007/10/03)
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- Ring opening of fluoroepoxyalcohols by nucleophiles
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The fluoroepoxyalcohols formed by diastereoselective or asymmetric epoxidation of o-fluoro secondary allylic alcohols can be transformed into various α-substituted ketols by nucleophiles.Key Words: fluoroepoxyalcohols / nucleophiles / α-substituted ketols
- Gosmini, C.,Sauvetre, R.,Normant, J. F.
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p. 236 - 241
(2007/10/02)
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- Asymmetric Transformation of 2-Phenyl- and 2-Chloroalkanoic Acids via Chiral Oxazolines
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Asymmetric transformation of racemic 2-phenyl- and 2-chloroalkanoic acids via oxazolines into the corresponding optically active acids was investigated using (S)-phenylalaninol as a chiral auxiliary.The asymmetric transformation was performed by metalatio
- Shibata, Saizo,Matsushita, Hajime,Kaneko, Hajime,Noguchi, Masao,Saburi, Masahiko,Yoshikawa, Sadao
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p. 3546 - 3551
(2007/10/02)
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