- INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
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The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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- AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS
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The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
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Paragraph 0941-0944
(2017/11/10)
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- Pyridazinylurea plant regulators
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Pyridazinylurea plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl or cycloalkyl, R1 is hydrogen or alkyl, each X independently is halogen, alkoxy, alkylthi or alkylsulfonyl, and p is 0, 1 or 2.
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- Substituted amino-hydrazinopyridazines
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Amino and substituted amino-hydrazinopyridazines, e.g., 4-methyl-amino-3-hydrazinopyridazine and 4-ethylamino-6-chloro-3-hydrazinopyridazine, are prepared from 3,4,6-trihalopyridazines and are active as hypotensive/antihypertensive agents.
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